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Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
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Lam, Yuko P. Y., Wootton, Christopher, Hands-Portman, Ian, Wei, Juan, Chiu, Cookson, Romero-Canelón, Isolda, Lermyte, Frederik, Barrow, Mark P. and O'Connor, Peter B. (2018) Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation? Chemical Communications, 54 (98). pp. 13853-13856. doi:10.1039/C8CC06675B ISSN 1359-7345.
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WRAP-deamidation-islet-amyloid-polypeptide-accelerate-amyloid-fibril-formation-O'Connor-2018.pdf - Accepted Version - Requires a PDF viewer. Download (3142Kb) | Preview |
Official URL: https://doi.org/10.1039/C8CC06675B
Abstract
Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amyloid polypeptide (hIAPP). Mutant hIAPP with iso-aspartic residue mutations at possible deamidation sites showed very different fibril formation behavior, which correlates with the observed deamidation-induced acceleration of hIAPP aggregation.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QD Chemistry | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Proteins -- Deamination, Amyloid, Polypeptides, Mass spectrometry | |||||||||||||||||||||
Journal or Publication Title: | Chemical Communications | |||||||||||||||||||||
Publisher: | Royal Society of Chemistry | |||||||||||||||||||||
ISSN: | 1359-7345 | |||||||||||||||||||||
Official Date: | 19 November 2018 | |||||||||||||||||||||
Dates: |
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Volume: | 54 | |||||||||||||||||||||
Number: | 98 | |||||||||||||||||||||
Page Range: | pp. 13853-13856 | |||||||||||||||||||||
DOI: | 10.1039/C8CC06675B | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
Date of first compliant deposit: | 19 November 2018 | |||||||||||||||||||||
Date of first compliant Open Access: | 19 November 2019 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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