The Library
A cell cycle and nutritional checkpoint controlling bacterial surface adhesion
Tools
Casadesús, Josep, Fiebig, Aretha, Herrou, Julien, Fumeaux, Coralie, Radhakrishnan, Sunish K., Viollier, Patrick H. and Crosson, Sean (2014) A cell cycle and nutritional checkpoint controlling bacterial surface adhesion. PLoS Genetics, 10 (1). e1004101. doi:10.1371/journal.pgen.1004101 ISSN 1553-7390.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1371/journal.pgen.1004101
Abstract
In natural environments, bacteria often adhere to surfaces where they form complex multicellular communities. Surface adherence is determined by the biochemical composition of the cell envelope. We describe a novel regulatory mechanism by which the bacterium, Caulobacter crescentus, integrates cell cycle and nutritional signals to control development of an adhesive envelope structure known as the holdfast. Specifically, we have discovered a 68-residue protein inhibitor of holdfast development (HfiA) that directly targets a conserved glycolipid glycosyltransferase required for holdfast production (HfsJ). Multiple cell cycle regulators associate with the hfiA and hfsJ promoters and control their expression, temporally constraining holdfast development to the late stages of G1. HfiA further functions as part of a ‘nutritional override’ system that decouples holdfast development from the cell cycle in response to nutritional cues. This control mechanism can limit surface adhesion in nutritionally sub-optimal environments without affecting cell cycle progression. We conclude that post-translational regulation of cell envelope enzymes by small proteins like HfiA may provide a general means to modulate the surface properties of bacterial cells.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | PLoS Genetics | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1553-7390 | ||||
Official Date: | 23 January 2014 | ||||
Dates: |
|
||||
Volume: | 10 | ||||
Number: | 1 | ||||
Article Number: | e1004101 | ||||
DOI: | 10.1371/journal.pgen.1004101 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |