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An intensive, active surveillance reveals continuous invasion and high diversity of rhinovirus in households
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Kamau, E., Onyango, C. O., Otieno, G. P., Kiyuka, P. K., Agoti, C. N., Medley, G. F., Cane, P. A., Nokes, D. James and Munywoki, P. K. (2019) An intensive, active surveillance reveals continuous invasion and high diversity of rhinovirus in households. Journal of Infectious Diseases, 219 (7). pp. 1049-1057. doi:10.1093/infdis/jiy621 ISSN 0022-1899.
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Official URL: https://doi.org/10.1093/infdis/jiy621
Abstract
We report on infection patterns in 5 households (78 participants) delineating the natural history of human rhinovirus (HRV). Nasopharyngeal collections were obtained every 3–4 days irrespective of symptoms, over a 6-month period, with molecular screening for HRV and typing by sequencing VP4/VP2 junction. Overall, 311/3468 (8.9%) collections were HRV positive: 256 were classified into 3 species: 104 (40.6%) HRV-A; 14 (5.5%) HRV-B, and 138 (53.9%) HRV-C. Twenty-six known HRV types (13 HRV-A, 3 HRV-B, and 10 HRV-C) were identified (A75, C1, and C35 being most frequent). We observed continuous invasion and temporal clustering of HRV types in households (range 5–13 over 6 months). Intrahousehold transmission was independent of clinical status but influenced by age. Most (89.0%) of HRV infection episodes were limited to <14 days. Individual repeat infections were frequent (range 1–7 over 6 months), decreasing with age, and almost invariably heterotypic, indicative of lasting type-specific immunity and low cross-type protection.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
Library of Congress Subject Headings (LCSH): | Rhinoviruses , Rhinoviruses -- Transmission -- Kenya | ||||||||||||
Journal or Publication Title: | Journal of Infectious Diseases | ||||||||||||
Publisher: | Oxford University Press | ||||||||||||
ISSN: | 0022-1899 | ||||||||||||
Official Date: | 1 April 2019 | ||||||||||||
Dates: |
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Volume: | 219 | ||||||||||||
Number: | 7 | ||||||||||||
Page Range: | pp. 1049-1057 | ||||||||||||
DOI: | 10.1093/infdis/jiy621 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Reuse Statement (publisher, data, author rights): | This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Infectious Diseases following peer review. The version of record Everlyn Kamau, Clayton O Onyango, Grieven P Otieno, Patience K Kiyuka, Charles N Agoti, Graham F Medley, Patricia A Cane, D James Nokes, Patrick K Munywoki, An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households, The Journal of Infectious Diseases, Volume 219, Issue 7, 1 April 2019, Pages 1049–1057, https://doi.org/10.1093/infdis/jiy621, is available online at: https://doi.org/10.1093/infdis/jiy621 | ||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
Date of first compliant deposit: | 21 November 2018 | ||||||||||||
Date of first compliant Open Access: | 4 April 2019 | ||||||||||||
RIOXX Funder/Project Grant: |
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