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Functional connectivity of the anterior cingulate cortex in depression and in health
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Rolls, Edmund T., Cheng, Wei, Gong, Weikang, Qiu, Jiang, Zhou, Chanjuan, Zhang, Jie, Lyu, Wujun, Ruan, Hongtao, Wei, Dongtao, Cheng, Ke, Meng, Jie, Xie, Peng and Feng, Jianfeng (2019) Functional connectivity of the anterior cingulate cortex in depression and in health. Cerebral Cortex, 29 (8). pp. 3617-3630. doi:10.1093/cercor/bhy236 ISSN 1047-3211.
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Official URL: https://doi.org/10.1093/cercor/bhy236
Abstract
The first voxel-level resting-state functional connectivity (FC) neuroimaging analysis of depression of the anterior cingulate cortex (ACC) showed in 282 patients with major depressive disorder compared with 254 controls, some higher, and some lower FCs. However, in 125 unmedicated patients, primarily increases of FC were found: of the subcallosal anterior cingulate with the lateral orbitofrontal cortex, of the pregenual/supracallosal anterior cingulate with the medial orbitofrontal cortex, and of parts of the anterior cingulate with the inferior frontal gyrus, superior parietal lobule, and with early cortical visual areas. In the 157 medicated patients, these and other FCs were lower than in the unmedicated group. Parcellation was performed based on the FC of individual ACC voxels in healthy controls. A pregenual subdivision had high FC with medial orbitofrontal cortex areas, and a supracallosal subdivision had high FC with lateral orbitofrontal cortex and inferior frontal gyrus. The high FC in depression between the lateral orbitofrontal cortex and the subcallosal parts of the ACC provides a mechanism for more non-reward information transmission to the ACC, contributing to depression. The high FC between the medial orbitofrontal cortex and supracallosal ACC in depression may also contribute to depressive symptoms.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Depression, Mental, Depressed persons, Cognitive neuroscience | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Cerebral Cortex | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | Oxford University Press | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1047-3211 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Official Date: | August 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 29 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number: | 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | pp. 3617-3630 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1093/cercor/bhy236 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Reuse Statement (publisher, data, author rights): | This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Edmund T Rolls, Wei Cheng, Weikang Gong, Jiang Qiu, Chanjuan Zhou, Jie Zhang, Wujun Lv, Hongtao Ruan, Dongtao Wei, Ke Cheng, Jie Meng, Peng Xie, Jianfeng Feng; Functional Connectivity of the Anterior Cingulate Cortex in Depression and in Health, Cerebral Cortex, , bhy236, is available online at:https://doi.org/10.1093/cercor/bhy236 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 22 January 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 12 November 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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