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Highly pathogenic clone of Shiga toxin–producing Escherichia coli O157:H7, England and Wales
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Byrne, Lisa, Dallman, Timothy J., Adams, Natalie, Mikhail, Amy F. W., McCarthy, Noel D. and Jenkins, Claire (2018) Highly pathogenic clone of Shiga toxin–producing Escherichia coli O157:H7, England and Wales. Emerging Infectious Diseases , 24 (12). pp. 2303-2308. doi:10.3201/eid2412.180409 ISSN 1080-6059.
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Official URL: http://dx.doi.org/10.3201/eid2412.180409
Abstract
We used whole-genome sequencing to investigate the evolutionary context of an emerging highly pathogenic strain of Shiga toxin–producing Escherichia coli (STEC) O157:H7 in England and Wales. A timed phylogeny of sublineage IIb revealed that the emerging clone evolved from a STEC O157:H7 stx-negative ancestor ≈10 years ago after acquisition of a bacteriophage encoding Shiga toxin (stx) 2a, which in turn had evolved from a stx2c progenitor ≈20 years ago. Infection with the stx2a clone was a significant risk factor for bloody diarrhea (OR 4.61, 95% CI 2.24–9.48; p<0.001), compared with infection with other strains within sublineage IIb. Clinical symptoms of cases infected with sublineage IIb stx2c and stx-negative clones were comparable, despite the loss of stx2c. Our analysis highlighted the highly dynamic nature of STEC O157:H7 Stx-encoding bacteriophages and revealed the evolutionary history of a highly pathogenic clone emerging within sublineage IIb, a sublineage not previously associated with severe clinical symptoms.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Escherichia coli O157:H7, Gene mapping, Phylogeny, Pathogenic bacteria, Molecular cloning | ||||||||||||||||||
Journal or Publication Title: | Emerging Infectious Diseases | ||||||||||||||||||
Publisher: | US Department of Health and Human Services | ||||||||||||||||||
ISSN: | 1080-6059 | ||||||||||||||||||
Official Date: | December 2018 | ||||||||||||||||||
Dates: |
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Volume: | 24 | ||||||||||||||||||
Number: | 12 | ||||||||||||||||||
Page Range: | pp. 2303-2308 | ||||||||||||||||||
DOI: | 10.3201/eid2412.180409 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 23 November 2018 | ||||||||||||||||||
Date of first compliant Open Access: | 23 November 2018 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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