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Polymers for fluorescence imaging of formaldehyde in living systems via the Hantzsch reaction
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Liu, Guoqiang, Shegiwal, Ataulla, Zeng, Yuan, Wei, Yen, Boyer, Cyrille, Haddleton, David M. and Tao, Lei (2018) Polymers for fluorescence imaging of formaldehyde in living systems via the Hantzsch reaction. ACS Macro Letters, 7 (11). pp. 1346-1352. doi:10.1021/acsmacrolett.8b00697 ISSN 2161-1653.
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WRAP-Polymers-fluorescence-imaging-formaldehyde-Haddleton-2018.pdf - Accepted Version - Requires a PDF viewer. Download (738Kb) | Preview |
Official URL: https://doi.org/10.1021/acsmacrolett.8b00697
Abstract
Formaldehyde (FA) has been detected via the Hantzsch reaction for many decades. However, the Hantzsch reaction has been rarely used to detect FA in biological systems due to the disadvantages of small-molecule probes (including toxicity and poor water solubility). In this study, polymeric fluorescent probes were developed to resolve these issues associated with small molecules, and FA in living systems was successfully detected via the Hantzsch reaction. These water-soluble polymers were easily scaled-up (∼25 g) by radical polymerization using commercial monomers. These polymers exhibited similar, albeit better, sensitivity to FA compared to water-soluble small molecules, primarily indicative of the advantages of polymers for the detection of FA via the Hantzsch reaction. The polymer structures were highly biocompatible with the probes; thus, these polymers can effectively detect endogenous FA in cells or zebrafish in a safe manner. This result confirmed the superiority of polymers in safety as biocompatible materials. This study highlights a straightforward method for exploring probes for the detection of FA in living systems. It offers functional polymers for bioimaging and extends the application scope of the Hantzsch reaction, reflecting the utility of a broad study of organic reactions in interdisciplinary fields as well as possible key implications in organic chemistry, analytical chemistry, and polymer chemistry.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Formaldehyde, Biological systems | ||||||||
Journal or Publication Title: | ACS Macro Letters | ||||||||
Publisher: | American Chemical Society (ACS) | ||||||||
ISSN: | 2161-1653 | ||||||||
Official Date: | 20 November 2018 | ||||||||
Dates: |
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Volume: | 7 | ||||||||
Number: | 11 | ||||||||
Page Range: | pp. 1346-1352 | ||||||||
DOI: | 10.1021/acsmacrolett.8b00697 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Re-use Statement: | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].” | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 27 February 2019 | ||||||||
Date of first compliant Open Access: | 22 October 2019 | ||||||||
RIOXX Funder/Project Grant: |
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