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The default mode network mediates the impact of infant regulatory problems on adult avoidant personality traits
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Bäuml, Josef G., Baumann, Nicole, Avram, Mihai, Bratec, Satja Mulej, Breeman, Linda, Berndt, Maria, Bilgin, Ayten, Jaekel, Julia, Wolke, Dieter and Sorg, Christian (2019) The default mode network mediates the impact of infant regulatory problems on adult avoidant personality traits. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4 (4). pp. 333-342. doi:10.1016/j.bpsc.2018.11.005 ISSN 2451-9022.
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Official URL: http://dx.doi.org/10.1016/j.bpsc.2018.11.005
Abstract
Background
Infant regulatory problems (RPs), i.e. problems with crying, feeding, and/or sleeping, are associated with behavioral and emotional problems in childhood. It is unclear, however, whether these behavioral and emotional problems persist into adulthood. The default mode (DMN) and salience networks (SN) support both interoceptive regulation and social/emotional abilities. We thus hypothesized that adults with infant RPs have more behavioral and emotional problems, mediated by DMN/SN alterations.
Methods
Within the scope of the Bavarian Longitudinal Study, adults (mean age 28 years; 50% females) with (N = 79) and without (N = 254) a history of multiple and/or persistent infant RPs were assessed by the Young Adult Self Report (YASR) to measure behavioral and emotional problems, and – in a sub-sample (N = 49 and N = 71) – by resting-state functional magnetic resonance imaging (rs-fMRI) to measure DMN/SN integrity via intrinsic functional connectivity (iFC).
Results
Compared to adults without infant RPs, adults with infant RPs had more total problems (p=0.002), internalizing problems (p = 0.005), and more avoidant personality traits (p < 0.001). They showed decreased iFC of the DMN and SN. DMN iFC-decreases were strongest in adults with multiple and persistent RPs and linked with avoidant personality traits (r = - 0.42, p = 0.006). Remarkably, DMN iFC-decrements fully mediated the association between infant RPs and adult avoidant personality traits.
Conclusions
Adults with infant RPs have more avoidant personality traits that are mediated by the DMN. Persistent/multiple infant RPs and the DMN may be targets to attenuate behavioral and emotional problems.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | R Medicine > RJ Pediatrics | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Pediatric neurology, Avoidance (Psychology), Avoidant personality disorder, Behavior disorders in children, Infants -- Development | |||||||||||||||
Journal or Publication Title: | Biological Psychiatry: Cognitive Neuroscience and Neuroimaging | |||||||||||||||
Publisher: | Elsevier | |||||||||||||||
ISSN: | 2451-9022 | |||||||||||||||
Official Date: | April 2019 | |||||||||||||||
Dates: |
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Volume: | 4 | |||||||||||||||
Number: | 4 | |||||||||||||||
Page Range: | pp. 333-342 | |||||||||||||||
DOI: | 10.1016/j.bpsc.2018.11.005 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Date of first compliant deposit: | 4 December 2018 | |||||||||||||||
Date of first compliant Open Access: | 16 November 2019 | |||||||||||||||
RIOXX Funder/Project Grant: |
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