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Hydrogel and organogel formation by hierarchical self-assembly of cyclic peptides nanotubes
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Shaikh, Huda, Rho, Julia Y., Macdougall, Laura, Gurnani, Pratik, Lunn, Andrew M., Yang, J. L., Huband, Steven, Mansfield, Edward D. H., Peltier, Raoul and Perrier, Sébastien (2018) Hydrogel and organogel formation by hierarchical self-assembly of cyclic peptides nanotubes. Chemistry - A European Journal, 24 (71). pp. 19066-19074. doi:10.1002/chem.201804576 ISSN 0947-6539.
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Official URL: http://dx.doi.org/10.1002/chem.201804576
Abstract
Breaking away from the linear structure of previously reported peptide‐based gelators, this study reports the first example of gel formation based on the use of cyclic peptides made of alternating d‐ and l‐amino acids, known to self‐assemble in solution to form long nanotubes. Herein, a library of cyclic peptides was systemically studied for their gelation properties in various solvents, uncovering key parameters driving both organogel and hydrogel formation. The hierarchical nature of the self‐assembly process in water was characterised by a combination of electron microscopy imaging and small‐angle X‐ray scattering, revealing a porous network of entangled nanofibres composed by the aggregation of several cyclic peptide nanotubes. Rheology measurements then confirmed the formation of soft hydrogels.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QD Chemistry | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Colloids, Cyclic peptides, Self-assembly (Chemistry), Nanofibers | |||||||||||||||
| Journal or Publication Title: | Chemistry - A European Journal | |||||||||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | |||||||||||||||
| ISSN: | 0947-6539 | |||||||||||||||
| Official Date: | 17 December 2018 | |||||||||||||||
| Dates: |
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| Volume: | 24 | |||||||||||||||
| Number: | 71 | |||||||||||||||
| Page Range: | pp. 19066-19074 | |||||||||||||||
| DOI: | 10.1002/chem.201804576 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Reuse Statement (publisher, data, author rights): | This is the peer reviewed version of the following article: H. Shaikh, J. Y. Rho, L. J. Macdougall, P. Gurnani, A. M. Lunn, J. Yang, S. Huband, E. D. H. Mansfield, R. Peltier, S. Perrier, Chem. Eur. J. 2018, 24, 19066., which has been published in final form at https://doi.org/10.1002/chem.201804576. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| Date of first compliant deposit: | 27 February 2019 | |||||||||||||||
| Date of first compliant Open Access: | 18 October 2019 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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