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Dynamic scheduling of multi-product continuous biopharmaceutical facilities : a hyper-heuristic framework
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Oyebolu, Folarin B., Allmendinger, Richard, Farid, Suzanne S. and Branke, Jürgen (2019) Dynamic scheduling of multi-product continuous biopharmaceutical facilities : a hyper-heuristic framework. Computers & Chemical Engineering, 125 . pp. 71-88. doi:10.1016/j.compchemeng.2019.03.002 ISSN 0098-1354.
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Official URL: http://dx.doi.org/10.1016/j.compchemeng.2019.03.00...
Abstract
The biopharmaceutical industry is increasingly interested in moving from batch to semi-continuous manufacturing processes. These continuous bioprocesses are more failure-prone and process failure is more consequential. In addition, the probability of failure is dependent on process run time which generally is determined independent of scheduling considerations. This work presents a discrete-event simulation of continuous bioprocesses in a scheduling environment. Dynamic scheduling policies are investigated to make operational decisions in a multiproduct manufacturing facility and react to process failure events and uncertain demand. First, different scheduling policies are adapted from the stochastic lot sizing literature and a novel look-ahead scheduling policy is proposed. Then, policy parameters (including process run time) are tuned using evolutionary algorithms. Our results demonstrate that the tuned policies perform much better than a policy that estimates policy parameters based on service level considerations and a policy based on a fixed cyclical sequence.
Item Type: | Journal Article | |||||||||
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Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
Divisions: | Faculty of Social Sciences > Warwick Business School | |||||||||
Library of Congress Subject Headings (LCSH): | Pharmaceutical biotechnology, Manufacturing processes | |||||||||
Journal or Publication Title: | Computers & Chemical Engineering | |||||||||
Publisher: | Pergamon | |||||||||
ISSN: | 0098-1354 | |||||||||
Official Date: | 9 June 2019 | |||||||||
Dates: |
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Volume: | 125 | |||||||||
Page Range: | pp. 71-88 | |||||||||
DOI: | 10.1016/j.compchemeng.2019.03.002 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Date of first compliant deposit: | 4 March 2019 | |||||||||
Date of first compliant Open Access: | 5 March 2019 | |||||||||
RIOXX Funder/Project Grant: |
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