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Editing streptomycete genomes in the CRISPR/Cas9 age

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Alberti, Fabrizio and Corre, Christophe (2019) Editing streptomycete genomes in the CRISPR/Cas9 age. Natural Product Reports, 36 (9). pp. 1237-1248. doi:10.1039/c8np00081f ISSN 0265-0568.

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Official URL: https://doi.org/10.1039/c8np00081f

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Abstract

This article aims to highlight advantages, drawbacks and issues that users should consider when implementing the use of CRISPR/Cas9-tools for genome editing in streptomycetes, the most prolific source of antimicrobial natural products to date. Here, we examine four toolkits that have so far been made available for streptomycete in vivo-engineering and one for in vitro-editing, and review how they have been applied over the last three years. Our critical evaluation of these toolkits intends to support potential users in determining what they could achieve, what they should consider and what system they should select/optimise for their application.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Gene editing, Genetic engineering, Anti-infective agents
Journal or Publication Title: Natural Product Reports
Publisher: Royal Society of Chemistry
ISSN: 0265-0568
Official Date: 25 January 2019
Dates:
DateEvent
25 January 2019Available
10 January 2019Accepted
Volume: 36
Number: 9
Page Range: pp. 1237-1248
DOI: 10.1039/c8np00081f
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 6 March 2019
Date of first compliant Open Access: 5 April 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/M022765/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M017982/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M017982/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
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