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Computational physiology of uterine smooth muscle
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Dunford, Joseph, Lutton, E. Josiah, Atia, Jolene, Blanks, Andrew M. and Van Den Berg, Hugo (2019) Computational physiology of uterine smooth muscle. Science Progress, 102 (2). pp. 103-126. doi:10.1177/0036850419850431 ISSN 0036-8504.
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WRAP-computational-physiology-uterine-smooth-muscle-van-den-Berg-2019.pdf - Accepted Version - Requires a PDF viewer. Download (6Mb) | Preview |
Official URL: https://doi.org/10.1177/0036850419850431
Abstract
Pregnancy can be accompanied by serious health risks to mother and child, such as pre-eclampsia, premature birth, and postpartum haemorrhage. Understanding of the normal physiology of uterine function is essential to an improved management of such risks. Here we focus on the physiology of the smooth muscle fibres that make up the bulk of the uterine wall, and which generate the forceful contractions that accompany parturition. We survey computational methods that integrate mathematical modelling with data analysis and thereby aid the discovery of new therapeutic targets that, according to clinical needs, can be manipulated to either stop contractions or cause the uterine wall muscle to become active.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QA Mathematics | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||||||
| Journal or Publication Title: | Science Progress | ||||||||
| Publisher: | Science Reviews 2000 Ltd. | ||||||||
| ISSN: | 0036-8504 | ||||||||
| Official Date: | 1 June 2019 | ||||||||
| Dates: |
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| Volume: | 102 | ||||||||
| Number: | 2 | ||||||||
| Page Range: | pp. 103-126 | ||||||||
| DOI: | 10.1177/0036850419850431 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | This is an Accepted Manuscript of an article published by Science Reviews 2000 Ltd in Science Progress on 20/05/2019, available online: https://doi.org/10.1177/0036850419850431 | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 24 April 2019 | ||||||||
| Date of first compliant Open Access: | 20 November 2020 | ||||||||
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