The Library
Preoperative and postoperative N-terminal pro B-type natriuretic peptide levels predict cardiac morbidity and mortality in patients undergoing colorectal cancer resection
Tools
Youssef, Haney, Collantes, Enrique, Hunter, James, Stinson, Julie, Smith, Steve, Stallard, Nigel, Been, Martin and Wong, Ling (2019) Preoperative and postoperative N-terminal pro B-type natriuretic peptide levels predict cardiac morbidity and mortality in patients undergoing colorectal cancer resection. Journal Of Colon And Rectal Cancer, 1 (3). pp. 1-9. doi:10.14302/issn.2471-7061.jcrc-18-2446 ISSN 2471-7061.
|
PDF
WRAP-preoperative-postoperative-N-terminal-pro-B-type-natriuretic-peptide-cardiac morbidity-mortality-colorectal-cancer-Stallard-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (407Kb) | Preview |
Official URL: http://dx.doi.org/10.14302/issn.2471-7061.jcrc-18-...
Abstract
Introduction
Cardiac complications are a major cause of perioperative morbidity and mortality in patients undergoing colorectal cancer surgery. A quick and reliable system for predicting postoperative cardiac morbidity is needed to predict cardiac events in order to improve outcome in surgery. The aim of this study was to investigate the role of the biochemical marker NT-proBNP in the prediction of postoperative all-cause mortality, cardiac-related mortality and cardiovascular events in patients undergoing colorectal cancer resections.
Methods
100 consecutive patients undergoing colorectal cancer surgery were prospectively recruited. Blood samples were taken preoperatively, 24h, 48h and 5-7 postoperative days to measure NT-proBNP levels. The predictive power of NT-proBNP levels was assessed using Receiver Operating Characteristics (ROC) curves.
Results
Cardiac-related morbidity and mortality was 9%. Of eleven deaths, 5 were cardiac-related. Preoperative NT-proBNP was a good predictor of death with ROC area under curve (AUC) of 0.83 (95% C.I. 0.673, 0.993) a strong predictor of cardiac death with AUC of 0.914 (95% C.I. 0.823, 1.000) and a good predictor of cardiac complications with AUC of 0.875 (95% C.I. 0.757, 0.993). NT-proBNP levels 24 hours and 48 hours postoperatively were also strongly predictive of postoperative cardiac morbidity and mortality.
Conclusion
Pre-and postoperative NT-proBNP have a role in predicting postoperative death and cardiac complications. This may have significant implications in the planning of postoperative care for high-risk patients.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||
Library of Congress Subject Headings (LCSH): | Colon (Anatomy) -- Cancer -- Treatment, Heart -- Diseases | ||||||||
Journal or Publication Title: | Journal Of Colon And Rectal Cancer | ||||||||
Publisher: | Open Access Pub | ||||||||
ISSN: | 2471-7061 | ||||||||
Official Date: | 2019 | ||||||||
Dates: |
|
||||||||
Volume: | 1 | ||||||||
Number: | 3 | ||||||||
Page Range: | pp. 1-9 | ||||||||
DOI: | 10.14302/issn.2471-7061.jcrc-18-2446 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 28 May 2019 | ||||||||
Date of first compliant Open Access: | 30 May 2019 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year