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Electrical polarization enables integrative quality control during bacterial differentiation into spores
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Sirec, Teja, Benarroch, Jonatan M., Buffard, Pauline, Garcia-Ojalvo, Jordi and Asally, Munehiro (2019) Electrical polarization enables integrative quality control during bacterial differentiation into spores. iScience, 16 . pp. 378-389. doi:10.1016/j.isci.2019.05.044 ISSN 2589-0042.
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Official URL: http://dx.doi.org/10.1016/j.isci.2019.05.044
Abstract
Quality control of offspring is important for the survival of cells. However, the mechanisms by which quality of offspring cells may be checked while running genetic programs of cellular differentiation remain unclear. Here we investigated quality control during sporulating in Bacillus subtilis by combining single-cell time-lapse microscopy, molecular biology and mathematical modelling. Our results revealed that the quality control via premature germination is coupled with the electrical polarization of outer membranes of developing forespores. The forespores which accumulate fewer cations on their surface are more likely to be aborted. This charge accumulation enables the projection of multi-dimensional information about the external environment and morphological development of the forespore into one-dimensional information of cation accumulation. We thus present a paradigm of cellular regulation by bacterial electrical signaling. Moreover, based on the insight we gain, we propose an electrophysiology-based approach of reducing the yield and quality of Bacillus endospores.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QR Microbiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Electrophysiology, Bacteria, Cell differentiation, Spores, Bacillus subtilis | ||||||||||||||||||||||||||||||
| Journal or Publication Title: | iScience | ||||||||||||||||||||||||||||||
| Publisher: | Cell Press | ||||||||||||||||||||||||||||||
| ISSN: | 2589-0042 | ||||||||||||||||||||||||||||||
| Official Date: | 28 July 2019 | ||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 16 | ||||||||||||||||||||||||||||||
| Page Range: | pp. 378-389 | ||||||||||||||||||||||||||||||
| DOI: | 10.1016/j.isci.2019.05.044 | ||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 5 June 2019 | ||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 10 June 2019 | ||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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