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Molecular features of Co-III tetra- and pentammines affect their influence on DNA structure
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UNSPECIFIED (2001) Molecular features of Co-III tetra- and pentammines affect their influence on DNA structure. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (9). pp. 2311-2316. ISSN 1434-1948.
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Abstract
The polyamines spermine and spermidine cause a range of structural effects on DNA. [Co(NH3)(6)](3+) is known to mimic many of these effects and we have shown previously that (+)[Co(en)(3)](3+) and (-)-[Co(en)(3)](3+) (en = ethylenediamine) do so as well. In this paper the effects of mono- and disubstitution of the Coin ammines by aqua, halo and nitro groups is explored. The overall effectiveness of the amines in conferring thermal stability on the ct-DNA proceeds in the order: spermine > (+)-[Co(en)(3)](3+) approximate to (-)-[Co(en)(3)](3+) approximate to [Co(NH3)(6)](3+) spermidine > [Pt(NH3)(4)](2+) > [Co(NH3)(5)H2O](3+) [Co(NH3)(5)Cl](2+) approximate to [Co(NH3)(5)Br](2+) > cis-[Co(en)(2)NH3Cl](2+) > [Co(NH3)(5)(NO2)](2+) = trans-(Co(NH3)(4)(H2O)(2)](3+); whereas the B -->Z transition-induction ordering is: spermine approximate to [Co(NH3)(6)](3+) > (+)-[Co(en)(3)](3+) = [Co(NH3)(5)(H2O)](3+) > (-)-[Co(en)(3)](3+) > [Co(NH3)(5)Br](2+) > [Co(NH3)(5)Cl](2+), with the other amines failing to cause the transition under the 11 mm salt concentration and temperature ramp conditions used; the DNA bending ranking is: spermine > [Co(NH3)(6)](3+) > (+)-[Co(en)(3)](3+) > (-)[Co(en)(3)](3+) > [Co(NH3)(5)(H2O)](3+) > trans-[Co(NH3)(4)(H2O)(2)](3+) > spermidine, with the other 2+ amines (the aquo complexes will be 2+ at neutral pH), especially the bromo and nitro compounds, having comparatively little effect. While the presentation of NNN triangular faces is found to be important in the B -->Z transition, the fact that the halo ligands are probably substituted by the DNA phosphates plays a role, especially in the DNA bending, where deep penetration of the major groove is concluded to be required. A favourable interaction between the backbone and the aquo ligands may enhance the B -->Z transition.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | ||||
Publisher: | WILEY-V C H VERLAG GMBH | ||||
ISSN: | 1434-1948 | ||||
Official Date: | September 2001 | ||||
Dates: |
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Number: | 9 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 2311-2316 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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