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Crystal chemistry and antibacterial properties of cupriferous hydroxyapatite
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Bhattacharjee, Arjak, Fang, Yanan, Hooper, Thomas, Kelly, Nicole L., Gupta, Disha, Balani, Kantesh, Manna, Indranil, Baikie, Tom, Bishop, Peter, White, Timothy and Hanna, John V. (2019) Crystal chemistry and antibacterial properties of cupriferous hydroxyapatite. Materials, 12 (11). 1814. doi:10.3390/ma12111814 ISSN 1996-1944.
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Official URL: http://dx.doi.org/10.3390/ma12111814
Abstract
Copper-doped hydroxyapatite (HA) of nominal composition Ca10(PO4)6[Cux(OH)2-2xOx] (0.0 ≤ x ≤ 0.8) was prepared by solid-state and wet chemical processing to explore the impact of the synthesis route and mode of crystal chemical incorporation of copper on the antibacterial efficacy against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) strains. Apatites prepared by solid-state reaction showed unit cell volume dilation from 527.17 Å3 for copper-free HA to 533.31 Å3 for material of the putative composition Ca10(PO4)6[Cu0.8(OH)0.4O0.8] consistent with Cu+ insertion into the [001] hydroxyapatite channel. This was less pronounced (528.30 Å3 to 529.3 Å3) in the corresponding wet chemical synthesised products, suggesting less complete Cu tunnel incorporation and partial tenancy of Cu in place of calcium. X-ray absorption spectroscopy suggests fast quenching is necessary to prevent oxidation of Cu+ to Cu2+. Raman spectroscopy revealed an absorption band at 630 cm−1 characteristic of symmetric O-Cu+-O units tenanted in the apatite channel while solid-state 31P magic-angle-spinning nuclear magnetic resonance (MAS NMR) supported a vacancy-Cu+ substitution model within the apatite channel. The copper doping strategy increases antibacterial efficiency by 25% to 55% compared to undoped HA, with the finer particle sizes and greater specific surface areas of the wet chemical material demonstrating superior efficacy.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics |
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Library of Congress Subject Headings (LCSH): | Hydroxyapatite, Antibacterial agents | ||||||||||||||||||||||||||||||
Journal or Publication Title: | Materials | ||||||||||||||||||||||||||||||
Publisher: | M D P I AG | ||||||||||||||||||||||||||||||
ISSN: | 1996-1944 | ||||||||||||||||||||||||||||||
Official Date: | 4 June 2019 | ||||||||||||||||||||||||||||||
Dates: |
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Volume: | 12 | ||||||||||||||||||||||||||||||
Number: | 11 | ||||||||||||||||||||||||||||||
Article Number: | 1814 | ||||||||||||||||||||||||||||||
DOI: | 10.3390/ma12111814 | ||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||
Date of first compliant deposit: | 13 June 2019 | ||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 13 June 2019 | ||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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