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Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens
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Hind, Charlotte K., Dowson, Christopher G., Sutton, J. Mark, Jackson, Thomas, Clifford, Melanie, Garner, R. Colin and Czaplewski, Lloyd (2019) Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens. Antimicrobial Agents and Chemotherapy, 63 . e00769. doi:10.1128/AAC.00769-19
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WRAP-evaluation-library-FDA-approved-drugs-potentiate-antibiotics-Dowson-2019.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1307Kb) | Preview |
Official URL: https://doi.org/10.1128/AAC.00769-19
Abstract
The Prestwick library was screened for antibacterial activity or 'antibiotic-resistance breaking' (ARB) potential against four species of Gram-negative pathogens. Discounting known antibacterials, the screen identified very few ARB hits, which were strain/drug specific. These ARB hits included antimetabolites (zidovudine, floxuridine, didanosine, gemcitabine), anthracyclines (daunorubicin, mitoxantrone, epirubicin) and psychoactive drugs (gabapentin, fluspirilene, oxethazaine). This suggests that there are few approved drugs which could be directly repositioned as adjunct-antibacterials and these will need robust testing to validate efficacy. [Abstract copyright: © Crown copyright 2019.]
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology S Agriculture > SF Animal culture |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Antibacterial agents, Antibiotic-producing organisms, Pathogenic microorganisms, Antibiotics, Multidrug resistance | ||||||||
| Journal or Publication Title: | Antimicrobial Agents and Chemotherapy | ||||||||
| Publisher: | American Society for Microbiology | ||||||||
| ISSN: | 0066-4804 | ||||||||
| Official Date: | 25 July 2019 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 20 June 2019 | ||||||||
| Volume: | 63 | ||||||||
| Article Number: | e00769 | ||||||||
| DOI: | 10.1128/AAC.00769-19 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
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