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Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens

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Hind, Charlotte K., Dowson, Christopher G., Sutton, J. Mark, Jackson, Thomas, Clifford, Melanie, Garner, R. Colin and Czaplewski, Lloyd (2019) Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens. Antimicrobial Agents and Chemotherapy, 63 . e00769. doi:10.1128/AAC.00769-19 ISSN 0066-4804.

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Official URL: https://doi.org/10.1128/AAC.00769-19

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Abstract

The Prestwick library was screened for antibacterial activity or 'antibiotic-resistance breaking' (ARB) potential against four species of Gram-negative pathogens. Discounting known antibacterials, the screen identified very few ARB hits, which were strain/drug specific. These ARB hits included antimetabolites (zidovudine, floxuridine, didanosine, gemcitabine), anthracyclines (daunorubicin, mitoxantrone, epirubicin) and psychoactive drugs (gabapentin, fluspirilene, oxethazaine). This suggests that there are few approved drugs which could be directly repositioned as adjunct-antibacterials and these will need robust testing to validate efficacy. [Abstract copyright: © Crown copyright 2019.]

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
S Agriculture > SF Animal culture
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Antibacterial agents, Antibiotic-producing organisms, Pathogenic microorganisms, Antibiotics, Multidrug resistance
Journal or Publication Title: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
ISSN: 0066-4804
Official Date: 25 July 2019
Dates:
DateEvent
25 July 2019Published
3 June 2019Available
3 June 2019Accepted
Volume: 63
Article Number: e00769
DOI: 10.1128/AAC.00769-19
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 20 June 2019
Date of first compliant Open Access: 20 June 2019

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