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Dual-action platinum(II) Schiff base complexes : photocytotoxicity and cellular imaging
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Banerjee, Samya, Capper, Miles S., Clarkson, Guy J., Huang, Huaiyi and Sadler, Peter J. (2019) Dual-action platinum(II) Schiff base complexes : photocytotoxicity and cellular imaging. Polyhedron, 172 . pp. 157-166. doi:10.1016/j.poly.2019.04.024 ISSN 0277-5387.
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WRAP-dual-action-platinum(II)-Schiff-base-complexes-photocytotoxicity-cellular-imaging-Sadler-2019.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3222Kb) | Preview |
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MS_PtSchiffBase_Scxript_SB3_PJS_HH1-prepare to submit.docx - Accepted Version Embargoed item. Restricted access to Registered users only Download (4Mb) |
Official URL: http://dx.doi.org/10.1016/j.poly.2019.04.024
Abstract
Nine photo-stable Pt(II) Schiff base complexes [Pt(O^N^N^O)] (Pt1–Pt9) containing tetradentate salicylaldimine chelating ligands have been synthesized and characterized as potential photosensitisers for photodynamic therapy (PDT). The effects of electron-withdrawing versus electron-donating substituents on their electronic spectral properties are investigated. Pt1–Pt9 show broad absorption bands between 400–600 nm, which makes them useful for green-light photodynamic therapy. The complexes showed intense phosphorescence with emission maxima at ca. 625 nm. This emission was used to track their cellular localization in cancer cells. Confocal cellular imaging showed that the complexes localized mostly in the cytoplasm. In the dark, the complexes were non-toxic to A549 human lung cancer cells, but exhibited high photo-toxicity upon low-dose green light (520 nm, 7.02 J/cm2) irradiation via photo-induced singlet oxygen generation. Thus, these photoactive Pt(II) complexes have the potential to overcome the problem of drug resistance and side effects of current clinical Pt(II) drugs, and to act as both theranostic as well as therapeutic agents.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Platinum, Schiff bases, Photochemotherapy , Cells -- Imaging, Active oxygen | ||||||||||||||||||||||||
Journal or Publication Title: | Polyhedron | ||||||||||||||||||||||||
Publisher: | Pergamon | ||||||||||||||||||||||||
ISSN: | 0277-5387 | ||||||||||||||||||||||||
Official Date: | 1 November 2019 | ||||||||||||||||||||||||
Dates: |
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Volume: | 172 | ||||||||||||||||||||||||
Page Range: | pp. 157-166 | ||||||||||||||||||||||||
DOI: | 10.1016/j.poly.2019.04.024 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||
Date of first compliant deposit: | 19 June 2019 | ||||||||||||||||||||||||
Date of first compliant Open Access: | 26 June 2019 | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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