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Research into the effect of sodium-glucose linked transporter 2 inhibition on left ventricular remodeling in patients with heart failure and diabetes mellitus
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Singh, Jagdeep S. S., Mordi, Ify, Mohan, Mohapradeep, Gandy, Stephen J., Pearson, Ewan, Houston, John G., Struthers, Allan D. and Lang, Chim C. (2018) Research into the effect of sodium-glucose linked transporter 2 inhibition on left ventricular remodeling in patients with heart failure and diabetes mellitus. In: American Diabetes Association, Florida. Published in: Diabetes, 67 (Supplement 1). 256-OR. ISSN 0012-1797.
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Official URL: https://diabetes.diabetesjournals.org/content/67/S...
Abstract
ween dapagliflozin and placebo in the primary endpoints of LV end diastolic volume (LVEDV) or LV end systolic volume (LVESV); +4.71mls; 95% CI: -17.to 26.50 and +1.52mls; 95% CI: -15.68 to 18.72 respectively. However, when an interaction term for starting LVEF was added to the model, dapagliflozin significantly lowered LVEDV, LVESV and LV mass in those with starting LVEF ≥ 45%; -15.59mls; p=0.019, -15.20mls; p=0.016 and -4.87gm/m2; p=0.026. Patients on dapagliflozin had weight reduction; -1.90kg; 95% CI: -3.83 to +0.04; p=0.054, lower diastolic BP; -6.34mmHg; 95% CI: -11.35 to -1.32; p=0.014 and higher hemoglobin; +1.23 g/dl; 95% CI: 0.65 to 1.82; p<0.001. They were also more likely to stop or reduce loop diuretics; 50.0% vs. 8.7%; p=0.005.
Conclusions: Our data show dapagliflozin treatment resulted in weight and blood pressure reduction among patients with DM and HFrEF. There was evidence to suggest that dapagliflozin may cause LV reverse remodelling in DM patients with mild, but not with more severe HFrEF.
Item Type: | Conference Item (Speech) | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Diabetes | ||||||
Publisher: | American Diabetes Association | ||||||
ISSN: | 0012-1797 | ||||||
Official Date: | 2018 | ||||||
Dates: |
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Volume: | 67 | ||||||
Number: | Supplement 1 | ||||||
Page Range: | 256-OR | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Conference Paper Type: | Speech | ||||||
Title of Event: | American Diabetes Association | ||||||
Type of Event: | Conference | ||||||
Location of Event: | Florida |
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