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ToF-SIMS and XPS study of photoactivatable reagents designed for surface glycoengineering part III. 5-carboxamidopentyl-N-[m-[3-(trifluoromethyl)diazirin-3-yl]phenyl-beta-D-galactopyranosyl]-(1-> 4)-1-thio-beta-D-glucopyranoside (lactose aryl diazirine) on diamond
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UNSPECIFIED (2001) ToF-SIMS and XPS study of photoactivatable reagents designed for surface glycoengineering part III. 5-carboxamidopentyl-N-[m-[3-(trifluoromethyl)diazirin-3-yl]phenyl-beta-D-galactopyranosyl]-(1-> 4)-1-thio-beta-D-glucopyranoside (lactose aryl diazirine) on diamond. SURFACE AND INTERFACE ANALYSIS, 31 (6). pp. 457-464. ISSN 0142-2421.
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Abstract
Time-of-night Secondary Ion Mass Spectrometry (ToF-SIMS) and x-ray photoelectron spectroscopy (XPS) are used to characterize a newly synthesized glycosylated photoactivatable reagent designed for surface glycoengineering. The immobilization on diamond surfaces of the glycoaryldiazirine reagent lactose aryl diazirine (5-carboxamidopentyl-N-[m-[3-(trifluoromethyl)diazirin-3-yl]phenyl-beta -D-galactopyransol]-(1->4)-thio-beta -D-glucopyranoside)-beta -D-glucopyranoside) is compared to a previously studied monoglycosylated photoactivatable reagent (MAD-Gal). The XPS atomic constituents and chemical shifts, as well as ToF-SIMS specific characteristic fragments and molecular peaks of the new photoimmobilized molecule are recorded. Spectral differences are identified in XPS C 1s spectra and in the high mass range of positive ion ToF-SIMS spectra for the surface immobilized disaccharide. The ToF-SIMS characteristic high-mass ions involve both cationization with Na+ and loss of the diazirine function. The results can be related to differences observed in biological assays with each of the surface immobilized saccharides. Copyright (C) 2001 John Wiley & Sons, Ltd.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | SURFACE AND INTERFACE ANALYSIS | ||||
Publisher: | JOHN WILEY & SONS LTD | ||||
ISSN: | 0142-2421 | ||||
Official Date: | June 2001 | ||||
Dates: |
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Volume: | 31 | ||||
Number: | 6 | ||||
Number of Pages: | 8 | ||||
Page Range: | pp. 457-464 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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