The Library
Five-year study assessing the clinical utility of anti-Müllerian hormone measurements in reproductive-age women with cancer
Tools
Palinska-Rudzka, K. E., Ghobara, T., Parsons, Nicholas R., Milner, J., Lockwood, G. and Hartshorne, Geraldine M. (2019) Five-year study assessing the clinical utility of anti-Müllerian hormone measurements in reproductive-age women with cancer. Reproductive Biomedicine Online, 39 (4). pp. 712-720. doi:10.1016/j.rbmo.2019.06.001 ISSN 1472-6483.
|
PDF
WRAP-Five-year-clinical-Müllerian-Hormone-age-women-cancer-Hartshorne-2019.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1314Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.rbmo.2019.06.001
Abstract
An important discussion point before chemotherapy is ovarian toxicity, a side-effect that profoundly affects young women with cancer. Their quality of life after successful treatment, including the ability to conceive, is a major concern. We asked whether serum anti-Müllerian hormone (AMH) measurements before chemotherapy for two most common malignancies are predictive of long-term changes in ovarian reserve? A prospective cohort study measured serum AMH in 66 young women with lymphoma and breast cancer, before and at 1 year and 5 years after chemotherapy, compared with 124 healthy volunteers of the same age range (18-43 years). Contemporaneously, patients reported their menses and live births during 5-year follow-up. After adjustment for age, serum AMH was 1.4 times higher (95% CI 1.1 to 1.9; P < 0.02) in healthy volunteers than in cancer patients before chemotherapy. A strong correlation was observed between baseline and 5-year AMH in the breast cancer group (P < 0.001, regression coefficient = 0.58, 95% CI 0.29 to 0.89). No significant association was found between presence of menses at 5 years and serum AMH at baseline (likelihood ratio test from logistics regression analysis). Reproductive-age women with malignancy have lower serum AMH than healthy controls even before starting chemotherapy. Pre-chemotherapy AMH was significantly associated with long-term ovarian function in women with breast cancer. At key time points, AMH measurements could be used as a reproductive health advisory tool for young women with cancer. Our results highlight the unsuitability of return of menstruation as a clinical indicator of ovarian reserve after chemotherapy. [Abstract copyright: Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.]
Item Type: | Journal Article | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics |
|||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Dean's Office & Professional Support Services Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
|||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Ovaries -- Cancer -- Diagnosis, Ovaries -- Cancer -- Treatment, Fertility, Human, Infertility, Female -- Prevention, Cancer -- Treatment -- Complications, Hormones -- Physiological effect | |||||||||
Journal or Publication Title: | Reproductive Biomedicine Online | |||||||||
Publisher: | Elsevier Ltd | |||||||||
ISSN: | 1472-6483 | |||||||||
Official Date: | October 2019 | |||||||||
Dates: |
|
|||||||||
Volume: | 39 | |||||||||
Number: | 4 | |||||||||
Page Range: | pp. 712-720 | |||||||||
DOI: | 10.1016/j.rbmo.2019.06.001 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Date of first compliant deposit: | 16 December 2019 | |||||||||
Date of first compliant Open Access: | 11 June 2020 | |||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year