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Monte Carlo code comparison of dose delivery prediction for microbeam radiation therapy
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De Felici, Marina, Siegbahn, Eric A., Spiga, Jenny, Hanson, A. L., Felici, Roberto, Ferrero, Claudio, Tartari, A., Gambaccini, Mauro, Keyriläinen, Jani, Bräuer-Krisch, Elke, Randaccio, Paolo and Bravin, Alberto (2008) Monte Carlo code comparison of dose delivery prediction for microbeam radiation therapy. Journal of Physics: Conference Series, 102 (1). 012005. doi:10.1088/1742-6596/102/1/012005 ISSN 1742-6596.
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Official URL: http://dx.doi.org/10.1088/1742-6596/102/1/012005
Abstract
Preclinical Microbeam Radiation Therapy (MRT) research programs are carried out at the European Synchrotron Radiation Facility (ESRF) and at a few other synchrotron facilities. MRT needs an accurate evaluation of the doses delivered to biological tissues for carrying out pre-clinical studies. This point is crucial for determining the effect induced by changing any of the physical irradiation parameters. The doses of interest in MRT are normally calculated using Monte Carlo (MC) methods. A few MC packages have been used in the last decade for MRT dose evaluations in independent studies. The aim of this investigation is to provide a preliminary basis to perform a systematic comparison of the dose results obtained, under identical irradiation conditions and for the same scoring geometries with the following five MC codes: EGS4, PENELOPE, GEANT4, EGSnrc, and MCNPX. Dose profiles have been calculated in an in-depth region of cylindrical phantoms made of water or PMMA. Beams in both cylindrical and planar geometry have been considered. This comparison shows an overall agreement among the different codes although minor differences occur, which need further investigations.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QC Physics | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||
Journal or Publication Title: | Journal of Physics: Conference Series | ||||||
Publisher: | Institute of Physics Publishing Ltd. | ||||||
ISSN: | 1742-6596 | ||||||
Official Date: | 1 February 2008 | ||||||
Dates: |
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Volume: | 102 | ||||||
Number: | 1 | ||||||
Article Number: | 012005 | ||||||
DOI: | 10.1088/1742-6596/102/1/012005 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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