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Tool development for metabolic analyses in the context of thermodynamic constraints
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Martinez Vernon, Andrea S. (2018) Tool development for metabolic analyses in the context of thermodynamic constraints. PhD thesis, University of Warwick.
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WRAP_Theses_Martinez Vernon_2018.pdf - Submitted Version - Requires a PDF viewer. Download (34Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b3402460~S15
Abstract
Metabolism is key to all biological processes. Studies have yet to establish the link between metabolism, extracellular electron transfer and thermodynamics. In this context, I successfully developed a platform to enable electrochemical experiments using strict anaerobic microorganisms to quantify the electron transfer in an effort to measure metabolic rates. This involved establishing a novel hypothesis to investigate “syntrophy over wires”. Moreover, I developed a computational tool, MetQy, to enable the automated, large–scale analysis of annotated genomes with metabolic information in the form of an R package. The work I presented here has paved the way for electrochemical and computational analyses towards characterising and better understanding metabolic–electronic interactions in the context of thermodynamics.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QP Physiology | ||||
Library of Congress Subject Headings (LCSH): | Metabolism -- Regulation, Metabolism -- Testing, Charge exchange, Thermodynamics | ||||
Official Date: | September 2018 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | School of Life Sciences | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Soyer, Orkun S. | ||||
Sponsors: | Engineering and Physical Sciences Research Council ; Biotechnology and Biological Sciences Research Council (Great Britain) | ||||
Format of File: | |||||
Extent: | xxi, 272 leaves : illustrations, charts, photographs | ||||
Language: | eng |
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