The Library
Towards symmetry driven and nature inspired UV filter design
Tools
Horbury, Michael D., Holt, Emily L., Mouterde, Lous M. M., Balaguer, Patrick, Cebrian, Juan, Blasco, Laurent, Allais, Florent and Stavros, Vasilios G. (2019) Towards symmetry driven and nature inspired UV filter design. Nature Communications, 10 . 4748 . doi:10.1038/s41467-019-12719-z ISSN 2041-1723.
|
PDF
WRAP-towards-symmetry-nature-filter-design-Stavros-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1073Kb) | Preview |
|
PDF
WRAP-Towards-symmetry-driven-nature-inspired-Horbury-2019.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1043Kb) |
Official URL: https://doi.org/10.1038/s41467-019-12719-z
Abstract
In plants, sinapate esters offer crucial protection from the deleterious effects of ultraviolet radiation exposure. These esters are a promising foundation for designing UV filters, particularly for the UVA region (400 – 315 nm), where adequate photoprotection is currently lacking. Whilst sinapate esters are highly photostable due to a cis-trans (and vice versa) photoisomerization, the cis-isomer can display increased genotoxicity; an alarming concern for current cinnamate ester-based human sunscreens. To eliminate this potentiality, here we synthesize a sinapate ester with equivalent cis- and trans-isomers. We investigate its photostability through innovative ultrafast spectroscopy on a skin mimic, thus modelling the as close to true environment of sunscreen formulas. These studies are complemented by assessing endocrine disruption activity and antioxidant potential. We contest, from our results, that symmetrically functionalized sinapate esters may show exceptional promise as nature-inspired UV filters in next generation sunscreen formulations.
Item Type: | Journal Article | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QC Physics Q Science > QK Botany R Medicine > RA Public aspects of medicine T Technology > TP Chemical technology |
|||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Ultraviolet radiation -- Physiological effect, Protective coatings, Environmental health, Solar radiation, Nature -- Design, Botanical chemistry, Plant molecular biology | |||||||||||||||||||||||||||
Journal or Publication Title: | Nature Communications | |||||||||||||||||||||||||||
Publisher: | Nature Publishing Group | |||||||||||||||||||||||||||
ISSN: | 2041-1723 | |||||||||||||||||||||||||||
Official Date: | 18 October 2019 | |||||||||||||||||||||||||||
Dates: |
|
|||||||||||||||||||||||||||
Volume: | 10 | |||||||||||||||||||||||||||
Article Number: | 4748 | |||||||||||||||||||||||||||
DOI: | 10.1038/s41467-019-12719-z | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Date of first compliant deposit: | 27 September 2019 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 20 December 2019 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
|
|||||||||||||||||||||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year