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Software-aided design of idealised programmable nucleic acid circuits
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Zarubiieva, Iuliia and Kulkarni, Vishwesh V. (2020) Software-aided design of idealised programmable nucleic acid circuits. In: Singh, Vijai, (ed.) Advances in Synthetic Biology. Singapore: Springer , pp. 129-151. ISBN 9789811500800
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Official URL: https://doi.org/10.1007/978-981-15-0081-7_8
Abstract
The idea to use nucleic acid as a substrate for design of programmable biomolecular circuits was first introduced almost four decades ago; however, up till now, the field of DNA computing holds many challenges and uncertainties to be discovered. This chapter describes the historical evolution of DNA programming along with its most noticeable breakthroughs till the current days, describes the basics of such important theoretical concepts as DNA strand displacement and Abstract Chemical Reaction Networks, and finally, familiarises the reader with various platforms for in silico synthesis and simulation of genetic circuits.
Item Type: | Book Item | |||||||||
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Subjects: | Q Science > QH Natural history > QH301 Biology T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | |||||||||
Library of Congress Subject Headings (LCSH): | Synthetic biology, Systems biology, Bioinformatics, Nucleic acids, Genomics -- Data processing, Genetic engineering | |||||||||
Publisher: | Springer | |||||||||
Place of Publication: | Singapore | |||||||||
ISBN: | 9789811500800 | |||||||||
Book Title: | Advances in Synthetic Biology | |||||||||
Editor: | Singh, Vijai | |||||||||
Official Date: | 14 April 2020 | |||||||||
Dates: |
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Page Range: | pp. 129-151 | |||||||||
DOI: | 10.1007/978-981-15-0081-7_8 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Copyright Holders: | © Springer Nature Singapore Pte Ltd. 2020 | |||||||||
Date of first compliant deposit: | 9 October 2019 | |||||||||
Date of first compliant Open Access: | 14 April 2022 | |||||||||
Funder: | BBSRC, EPSRC | |||||||||
RIOXX Funder/Project Grant: |
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