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Sites of persistence of Fusobacterium necrophorum and Dichelobacter nodosus: a paradigm shift in understanding the epidemiology of footrot in sheep
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Clifton, Rachel, Giebel, Katharina, Liu, Nicola, Purdy, Kevin J. and Green, Laura E. (2019) Sites of persistence of Fusobacterium necrophorum and Dichelobacter nodosus: a paradigm shift in understanding the epidemiology of footrot in sheep. Scientific Reports, 9 (1). 14429. doi:10.1038/s41598-019-50822-9 ISSN 2045-2322.
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Official URL: https://doi.org/10.1038/s41598-019-50822-9
Abstract
Sites of persistence of bacterial pathogens contribute to disease dynamics of bacterial diseases. Footrot is a globally important bacterial disease that reduces health and productivity of sheep. It is caused by Dichelobacter nodosus, a pathogen apparently highly specialised for feet, while Fusobacterium necrophorum, a secondary pathogen in footrot is reportedly ubiquitous on pasture. Two prospective longitudinal studies were conducted to investigate the persistence of D. nodosus and F. necrophorum in sheep feet, mouths and faeces, and in soil. Molecular tools were used to detect species, strains and communities. In contrast to the existing paradigm, F. necrophorum persisted on footrot diseased feet, and in mouths and faeces; different strains were detected in feet and mouths. D. nodosus persisted in soil and on diseased, but not healthy, feet; similar strains were detected on both healthy and diseased feet of diseased sheep. We conclude that D. nodosus and F. necrophorum depend on sheep for persistence but use different strategies to persist and spread between sheep within and between flocks. Elimination of F. necrophorum would be challenging due to faecal shedding. In contrast D. nodosus could be eliminated if all footrot-affected sheep were removed and fade out of D. nodosus occurred in the environment before re-infection of a foot.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology S Agriculture > SF Animal culture |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Footrot in sheep -- Research, Fusobacterium, Microbial ecology | ||||||||||||||||||
| Journal or Publication Title: | Scientific Reports | ||||||||||||||||||
| Publisher: | Nature Publishing Group | ||||||||||||||||||
| ISSN: | 2045-2322 | ||||||||||||||||||
| Official Date: | 8 October 2019 | ||||||||||||||||||
| Dates: |
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| Volume: | 9 | ||||||||||||||||||
| Number: | 1 | ||||||||||||||||||
| Article Number: | 14429 | ||||||||||||||||||
| DOI: | 10.1038/s41598-019-50822-9 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | ** From PubMed via Jisc Publications Router ** History: received 16-06-2019; accepted 05-09-2019. | ||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
| Date of first compliant deposit: | 31 October 2019 | ||||||||||||||||||
| Date of first compliant Open Access: | 31 October 2019 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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