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Chromosome errors in human eggs shape natural fertility over reproductive life span
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(2019) Chromosome errors in human eggs shape natural fertility over reproductive life span. Science, 365 (6460). pp. 1466-1469. doi:10.1126/science.aav7321 ISSN 0036-8075.
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WRAP-Chromosome-erors-human-eggs-fertility-span-Hartshorne-2019.pdf - Accepted Version - Requires a PDF viewer. Download (940Kb) | Preview |
Official URL: http://doi.org/10.1126/science.aav7321
Abstract
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans. [Abstract copyright: Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.]
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QH Natural history R Medicine > RB Pathology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Dean's Office & Professional Support Services Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Aneuploidy, Human chromosome abnormalities | ||||||||
Journal or Publication Title: | Science | ||||||||
Publisher: | American Association for the Advancement of Science | ||||||||
ISSN: | 0036-8075 | ||||||||
Official Date: | 27 September 2019 | ||||||||
Dates: |
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Volume: | 365 | ||||||||
Number: | 6460 | ||||||||
Page Range: | pp. 1466-1469 | ||||||||
DOI: | 10.1126/science.aav7321 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.“This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 365 27/09/2019, http://doi.org/10.1126/science.aav7321 | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Copyright Holders: | Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. | ||||||||
Date of first compliant deposit: | 16 December 2019 | ||||||||
Date of first compliant Open Access: | 16 December 2019 |
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