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Defect-related luminescent nanostructured hydroxyapatite promotes mineralization through both intracellular and extracellular pathways
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Dai, Chunyan, Zhu, Linhua, Chen, Guangying and Haddleton, David M. (2019) Defect-related luminescent nanostructured hydroxyapatite promotes mineralization through both intracellular and extracellular pathways. RSC Advances , 9 (62). pp. 35939-35947. doi:10.1039/C9RA06629B ISSN 2046-2069.
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WRAP-defect-related-luminescent-nanostructured-hydroxyapatite-promotes-mineralization-intracellular-extracellular-pathways-Haddleton-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial. Download (2368Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/C9RA06629B
Abstract
Hydroxyapatite (HAP) is a widely used biomaterial for bone tissue substitution due to its chemical similarity with the natural bone. Defect-related luminescent HAP materials have the same chemical composition as normal HAP and excellent biocompatibility. However, only few works have focused on the defect-related luminescent HAP materials on bone regeneration. In this work, we systematically investigated the bone regeneration pathway induced by nanostructured particles using defect-related luminescent hydroxyapatite (S2) materials. We monitored the subcellular distribution and location of S2 during osteoblast differentiation with the property of defect-related luminescence. Nano-scale S2 could be internalized by osteoblasts (OBs) via caveolae-mediated endocytosis and macropinocytosis. S2 incorporated into the lysosomes dissolved and released calcium ions for the formation of mineralized nodules. Extracellular S2 also promoted bone regeneration as a nucleation site. Taken together, the physical properties of hydroxyapatite control the bone regeneration pathway in osteoblasts.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QE Geology R Medicine > RD Surgery T Technology > T Technology (General) T Technology > TN Mining engineering. Metallurgy |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Hydroxyapatite, Hydroxyapatite coating -- Technological innovations, Bone regeneration -- Technological innovations, Biomedical materials, Nanotechnology, Hydroxyapatite coating, Bone regeneration | |||||||||||||||||||||
| Journal or Publication Title: | RSC Advances | |||||||||||||||||||||
| Publisher: | Royal Society of Chemistry | |||||||||||||||||||||
| ISSN: | 2046-2069 | |||||||||||||||||||||
| Official Date: | 2019 | |||||||||||||||||||||
| Dates: |
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| Volume: | 9 | |||||||||||||||||||||
| Number: | 62 | |||||||||||||||||||||
| Page Range: | pp. 35939-35947 | |||||||||||||||||||||
| DOI: | 10.1039/C9RA06629B | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
| Date of first compliant deposit: | 14 November 2019 | |||||||||||||||||||||
| Date of first compliant Open Access: | 19 November 2019 | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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