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Metabolic inflexibility in women with polycystic ovary syndrome : a systematic review
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Rimmer, Michael, Tan, Bee K., Teede, Helena, Thangaratinam, Shakila and Al Wattar, Bassel H. (2020) Metabolic inflexibility in women with polycystic ovary syndrome : a systematic review. Gynecological Endocrinology . pp. 1-7. doi:10.1080/09513590.2019.1698025 ISSN 0951-3590.
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WRAP-metabolic-inflexibility-women-polycystic-review-Al-Wattar-2020.pdf - Accepted Version - Requires a PDF viewer. Download (715Kb) | Preview |
Official URL: https://doi.org/10.1080/09513590.2019.1698025
Abstract
Polycystic ovary syndrome (PCOS) is a risk factor for dysglycemia, insulin resistance, and type 2 Diabetes Mellitus (T2DM). Inefficient energy oxidation, metabolic inflexibility, is a marker of blunted metabolism. We conducted a systematic review on metabolic inflexibility in women with PCOS. We searched MEDLINE, EMBASE and Cochrane central (inception-October 2018) for studies evaluating metabolic inflexibility and reporting on changes in Respiratory Quotient (ΔRQ). We extracted data and assessed quality using The Newcastle–Ottawa Scale. We included five prospective cohort studies (461 women). Three compared PCOS women to unaffected subjects, one to women with obesity or T2DM, and one to adolescent girls; all had medium quality. Three studies showed higher metabolic inflexibility in women with PCOS (ΔRQ range 0.05–0.098) compared to unaffected subjects. Women with PCOS had similar metabolic inflexibility compared to those with T2DM (ΔRQ 0.05 ± 0.03 vs 0.06 ± 0.04, p = .98) and obesity (p = .06). Inflexibility was higher in hyperandrogenemic women with PCOS (ΔRQ 0.091 ± 0.060 vs 0.120 ± 0.010, p = .014). ΔRQ was lower in PCOS women with insulin resistance vs those with normal insulin sensitivity (0.04 ± 0.02 vs. 0.07 ± 0.04, p = .007). In conclusion, women with polycystic ovary syndrome appear to have higher metabolic inflexibility associated with hyperandrogenemia and insulin resistance.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Polycystic ovary syndrome -- Etiology -- Research, Metabolism -- Regulation | ||||||||
Journal or Publication Title: | Gynecological Endocrinology | ||||||||
Publisher: | Taylor & Francis (Routledge) | ||||||||
ISSN: | 0951-3590 | ||||||||
Official Date: | 2020 | ||||||||
Dates: |
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Page Range: | pp. 1-7 | ||||||||
DOI: | 10.1080/09513590.2019.1698025 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | “This is an Accepted Manuscript of an article published by Taylor & Francis in Gynecological Endocrinology on 03/12/2019, available online: http://www.tandfonline.com/10.1080/09513590.2019.1698025” | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 15 January 2020 | ||||||||
Date of first compliant Open Access: | 3 December 2020 | ||||||||
RIOXX Funder/Project Grant: |
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