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Assessing the impact of aggregating disease stage data in model predictions of human African trypanosomiasis transmission and control activities in Bandundu province (DRC)
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Castano, Maria Soledad, Ndeffo-Mbah, Martial L., Rock, Kat S., Palmer, Cody, Knock, Edward, Mwamba Miaka, Mwamba Miaka, Ndung'u, Joseph M., Torr, Steve, Verle, Paul , Spencer, Simon E. F., Galvani, Alison P., Bever, Caitlin and Keeling, Matthew James (2020) Assessing the impact of aggregating disease stage data in model predictions of human African trypanosomiasis transmission and control activities in Bandundu province (DRC). PLoS Neglected Tropical Diseases, 14 (1). e0007976. ISSN 1935-2727.
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Abstract
Since the turn of the century, the global community has made great progress towards the elimination of gambiense human African trypanosomiasis (HAT). Elimination programs, primarily relying on screening and treatment campaigns, have also created a rich database of HAT epidemiology. Mathematical models calibrated with these data can help to fill remaining gaps in our understanding of HAT transmission dynamics, including key operational research questions such as whether integrating vector control with current intervention strategies is needed to achieve HAT elimination. Here we explore, via an ensemble of models and simulation studies, how including or not disease stage data, or using more updated data sets affect model predictions of future control strategies.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Science > Statistics |
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Library of Congress Subject Headings (LCSH): | African trypanosomiasis, African trypanosomiasis -- Transmission -- Mathematical models -- Congo (Democratic Republic) -- Bandundu , African trypanosomiasis -- Control -- Mathematical models -- Congo (Democratic Republic) -- Bandundu , Trypanosomiasis | |||||||||||||||||||||
Journal or Publication Title: | PLoS Neglected Tropical Diseases | |||||||||||||||||||||
Publisher: | Public Library of Science | |||||||||||||||||||||
ISSN: | 1935-2727 | |||||||||||||||||||||
Official Date: | 21 January 2020 | |||||||||||||||||||||
Dates: |
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Volume: | 14 | |||||||||||||||||||||
Number: | 1 | |||||||||||||||||||||
Article Number: | e0007976 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 6 January 2020 | |||||||||||||||||||||
Date of first compliant Open Access: | 13 February 2020 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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