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Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status
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Coussa, Ayla, Hassan, Hayder and Barber, Thomas M. (2020) Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status. Journal of Assisted Reproduction and Genetics, 37 . pp. 1267-1272. doi:10.1007/s10815-020-01756-z ISSN 1058-0468.
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WRAP-impact-contraception-IVF-hormones-metabolic-endocrine-inflammatory-status-Barber-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (268Kb) | Preview |
Official URL: http://dx.doi.org/10.1007/s10815-020-01756-z
Abstract
Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases). Amongst ART, in vitro fertilization (IVF) is the most popular. IVF treatment may predispose the mother to increased risks and complications during pregnancy, and there may be adverse fetal outcomes. Hormonal therapies, including oral contraceptives, may impair glucose and lipid metabolism, and promote insulin resistance and inflammation. IVF treatment involves administration of reproductive hormones, similar in composition but in much higher doses than those used for oral contraception. The provision of IVF reproductive hormones to mice associates with glucose intolerance. In addition, the physiological and hormonal changes of pregnancy can trigger an inflammatory response, and metabolic and endocrine changes. There is controversy regarding the potential effects of IVF hormonal therapies in the promotion of diabetogenic and inflammatory states, additional to those that occur during pregnancy, and which may therefore predispose women with IVF-conceived pregnancies to adverse obstetric outcomes compared with women with spontaneously conceived pregnancies. This review summarizes the limited published evidence regarding the effect of IVF-based fertility therapies on glucose homeostasis, insulin resistance, cardio-metabolic profile, and markers of inflammation.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RC Internal medicine R Medicine > RG Gynecology and obstetrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Human reproductive technology , Human reproductive technology -- Complications, Ovaries -- Diseases, Infertility, Fertilization in vitro, Human , Pregnancy -- Complications | ||||||||
Journal or Publication Title: | Journal of Assisted Reproduction and Genetics | ||||||||
Publisher: | Springer New York LLC | ||||||||
ISSN: | 1058-0468 | ||||||||
Official Date: | June 2020 | ||||||||
Dates: |
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Volume: | 37 | ||||||||
Page Range: | pp. 1267-1272 | ||||||||
DOI: | 10.1007/s10815-020-01756-z | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 30 March 2020 | ||||||||
Date of first compliant Open Access: | 30 March 2020 |
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