Jeve, Yadava B. (2018) Role of ovum in reproductive outcomes. PhD thesis, University of Warwick.

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Abstract

The ovary is one of the most dynamic organs in the human body. Ovaries have a finite pool of follicles during fetal life. On-going follicular atresia significantly contributes to a quantitative and qualitative decline in ovarian reserve. Only a tiny number of follicles are released between puberty and menopause in the form of ovulation. Reproductive outcome following assisted conception significantly depends upon the quality and quantity of oocytes. Ovarian reserve is a significant predictor of ovarian response during the assisted conception treatment cycle. It not only determines the number of oocytes to be collected but also controls the pregnancy outcome. The first two publications evaluate the prediction of ovarian reserve and management of the poor ovarian reserve. The third and fourth publications analyse use of donor oocyte as a treatment option and the pregnancy complications associated with donor oocyte. The fifth publication examines the factors affecting fertilisation rates in assisted conception and strategies to improve the fertilisation process. Poor quality oocytes and the resultant poor-quality embryo is one of the primary causes for miscarriage in natural and assisted conception. The sixth and seventh publications discuss the diagnosis and management of miscarriages. These publications have significant clinical and research implications which are discussed in results and discussion chapter. Especially sixth publication contributed to changing the national guideline on the diagnosis of missed miscarriage. Recent research updates that occurred after our research period are discussed in a separate chapter. Further research is required to manage the reproductive outcomes related to the poor quantity and quality of oocytes.

Item Type:	Thesis or Dissertation (PhD)
Subjects:	Q Science > QL Zoology Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics
Library of Congress Subject Headings (LCSH):	Ovum, Ovarian atresia, Fetus, Puberty, Menopause, Ovulation
Official Date:	September 2018
Dates:	Date Event September 2018 Published
Institution:	University of Warwick
Theses Department:	Warwick Medical School
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Sutcliffe, Paul ; Tan, Bee
Format of File:	pdf
Extent:	61, 10, 5, 1, 262, 81, 158, 10, 19, 496, 169 leaves: illustrations, charts, plates
Language:	eng

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