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Sleep disturbances and the at risk mental state : a systematic review and meta-analysis
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Clarke, Latoya, Chisholm, Katherine, Cappuccio, Francesco P., Tang, Nicole K. Y., Miller, Michelle A., Elahi, Farah and Thompson, Andrew D. (2021) Sleep disturbances and the at risk mental state : a systematic review and meta-analysis. Schizophrenia Research, 227 . pp. 81-91. doi:10.1016/j.schres.2020.06.027 ISSN 0920-9964.
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Official URL: https://doi.org/10.1016/j.schres.2020.06.027
Abstract
Aims: To synthesise and investigate how sleep disturbances relate to psychotic symptoms, functioning and Quality of Life (QoL) in At Risk Mental State (ARMS) youth.
Method: A comprehensive search of six databases (MEDLINE, PsycINFO, Embase, CINAHL, Web of Science and CENTRAL) was conducted. Eligible studies provided data on sleep disturbances or disorders in ARMS patients.
Results: Sixteen studies met the inclusion criteria (n=1962 ARMS patients) including 7 cross-sectional studies, 2 RCT’s and 7 cohort studies.Narrative synthesis revealed that self-reported sleep (e.g., general disturbances, fragmented night time sleep and nightmares) was poorer among ARMS patients compared to healthy controls. In the limited studies (n=4) including objective measurements of sleep disturbances, ARMS patients experienced higher levels of movement during sleep, more daytime naps and increased sleep latency compared to controls. Furthermore, sleep disturbances were associated with attenuated psychotic symptoms and functional outcomes cross-sectionally and longitudinally. Only one study investigated the relationship between sleep and QoL. The exploratory meta-analysis revealed a significant difference in self-reported sleep disturbances measured by the PSQI (mean difference in score: 3.30 (95% CI 1.87, 4.74), p<0.00001) and SIPS (mean difference in score: 1.58 (95% CI 0.80, 2.35), p<0.00001) of ARMS patients compared to control groups.
Conclusions: ARMS individuals report impaired sleep quality and reduced sleep quantity compared to healthy controls. However, further research is needed to explore the longitudinal relationship between sleep disruptions and QoL in early psychosis. Significant variations in how sleep is measured across studies highlights a need to assess disturbances to sleep using robust and consistent approaches in this patient group.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Schizophrenia Research | ||||||||
| Publisher: | Elsevier BV | ||||||||
| ISSN: | 0920-9964 | ||||||||
| Official Date: | January 2021 | ||||||||
| Dates: |
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| Volume: | 227 | ||||||||
| Page Range: | pp. 81-91 | ||||||||
| DOI: | 10.1016/j.schres.2020.06.027 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 2 July 2020 | ||||||||
| Date of first compliant Open Access: | 3 August 2020 | ||||||||
| RIOXX Funder/Project Grant: |
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