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100th anniversary of macromolecular science viewpoint : re-engineering cellular interfaces with synthetic macromolecules using metabolic glycan labeling
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Tomás, Ruben M. F. and Gibson, Matthew I. (2020) 100th anniversary of macromolecular science viewpoint : re-engineering cellular interfaces with synthetic macromolecules using metabolic glycan labeling. ACS Macro Letters . pp. 991-1003. doi:10.1021/acsmacrolett.0c00317 ISSN 2161-1653.
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Official URL: http://dx.doi.org/10.1021/acsmacrolett.0c00317
Abstract
Cell-surface functionality is largely programmed by genetically encoded information through modulation of protein expression levels, including glycosylation enzymes. Genetic tools enable control over protein-based functionality, but are not easily adapted to recruit non-native functionality such as synthetic polymers and nanomaterials to tune biological responses and attach therapeutic or imaging payloads. Similar to how polymer–protein conjugation evolved from nonspecific PEGylation to site-selective bioconjugates, the same evolution is now occurring for polymer–cell conjugation. This Viewpoint discusses the potential of using metabolic glycan labeling to install bio-orthogonal reactive cell-surface anchors for the recruitment of synthetic polymers and nanomaterials to cell surfaces, exploring the expanding therapeutic and diagnostic potential. Comparisons to conventional approaches that target endogenous membrane components, such as hydrophobic, protein coupling and electrostatic conjugation, as well as enzymatic and genetic tools, have been made to highlight the huge potential of this approach in the emerging cellular engineering field.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QC Physics Q Science > QH Natural history T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||
Library of Congress Subject Headings (LCSH): | Cell membranes, Nanostructured materials , Polymers , Metabolic conjugation | ||||||||||||
Journal or Publication Title: | ACS Macro Letters | ||||||||||||
Publisher: | American Chemical Society | ||||||||||||
ISSN: | 2161-1653 | ||||||||||||
Official Date: | 25 June 2020 | ||||||||||||
Dates: |
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Page Range: | pp. 991-1003 | ||||||||||||
DOI: | 10.1021/acsmacrolett.0c00317 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Reuse Statement (publisher, data, author rights): | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].” | ||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
RIOXX Funder/Project Grant: |
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