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The genetic factors of bilaterian evolution

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Heger, Peter, Zheng, Wen, Rottmann, Anna, Panfilio, Kristen A. and Wiehe, Thomas (2020) The genetic factors of bilaterian evolution. eLife, 9 . e45530. doi:10.7554/eLife.45530 ISSN 2050-084X.

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Official URL: http://dx.doi.org/10.7554/eLife.45530

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Abstract

The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship.

Item Type: Journal Article
Subjects: Q Science > QE Geology
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Evolutionary developmental biology, Evolutionary paleobiology, Paleontology -- Cambrian, Biodiversity -- Climatic factors
Journal or Publication Title: eLife
Publisher: eLife Sciences Publications Ltd.
ISSN: 2050-084X
Official Date: 16 July 2020
Dates:
DateEvent
16 July 2020Published
3 July 2020Accepted
Volume: 9
Article Number: e45530
DOI: 10.7554/eLife.45530
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 27 July 2020
Date of first compliant Open Access: 28 July 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
CRC 680Deutsche Stiftung Friedensforschunghttp://dx.doi.org/10.13039/501100007450
CRC 1211Deutsche Stiftung Friedensforschunghttp://dx.doi.org/10.13039/501100007450
CRC 680Deutsche Stiftung Friedensforschunghttp://dx.doi.org/10.13039/501100007450

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