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The genetic factors of bilaterian evolution
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Heger, Peter, Zheng, Wen, Rottmann, Anna, Panfilio, Kristen A. and Wiehe, Thomas (2020) The genetic factors of bilaterian evolution. eLife, 9 . e45530. doi:10.7554/eLife.45530
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WRAP-Genetic-factors-bilaterian-evolution-Panfilio-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (21Mb) | Preview |
Official URL: http://dx.doi.org/10.7554/eLife.45530
Abstract
The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QE Geology Q Science > QH Natural history > QH301 Biology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Evolutionary developmental biology, Evolutionary paleobiology, Paleontology -- Cambrian, Biodiversity -- Climatic factors | ||||||||||||
| Journal or Publication Title: | eLife | ||||||||||||
| Publisher: | eLife Sciences Publications Ltd. | ||||||||||||
| ISSN: | 2050-084X | ||||||||||||
| Official Date: | 16 July 2020 | ||||||||||||
| Dates: |
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| Date of first compliant deposit: | 27 July 2020 | ||||||||||||
| Volume: | 9 | ||||||||||||
| Article Number: | e45530 | ||||||||||||
| DOI: | 10.7554/eLife.45530 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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