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Structures of the stator complex that drives rotation of the bacterial flagellum
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Deme, Justin C., Johnson, Steven, Vickery, Owen N., Muellbauer, Amy, Monkhouse, Holly, Griffiths, Thomas, Hennell James, Rory, Berks, Ben C., Coulton, James W., Stansfeld, Phillip J. and Lea, Susan M. (2020) Structures of the stator complex that drives rotation of the bacterial flagellum. Nature microbiology, 5 . pp. 1553-1564. doi:10.1038/s41564-020-0788-8 ISSN 2058-5276.
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Official URL: https://doi.org/10.1038/s41564-020-0788-8
Abstract
The bacterial flagellum is the prototypical protein nanomachine and comprises a rotating helical propeller attached to a membrane-embedded motor complex. The motor consists of a central rotor surrounded by stator units that couple ion flow across the cytoplasmic membrane to generate torque. Here, we present the structures of the stator complexes from Clostridium sporogenes, Bacillus subtilis and Vibrio mimicus, allowing interpretation of the extensive body of data on stator mechanism. The structures reveal an unexpected asymmetric A5B2 subunit assembly where the five A subunits enclose the two B subunits. Comparison to structures of other ion-driven motors indicates that this A5B2 architecture is fundamental to bacterial systems that couple energy from ion flow to generate mechanical work at a distance and suggests that such events involve rotation in the motor structures.
Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Subjects: | Q Science > QR Microbiology | |||||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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Library of Congress Subject Headings (LCSH): | Flagella (Microbiology) , Microorganisms -- Motility | |||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Nature microbiology | |||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | Nature Publishing Group | |||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 2058-5276 | |||||||||||||||||||||||||||||||||||||||||||||||||||
Official Date: | December 2020 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Volume: | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | pp. 1553-1564 | |||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1038/s41564-020-0788-8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 27 August 2020 | |||||||||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 14 March 2021 | |||||||||||||||||||||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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