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Adaptive immunity selects against malaria infection blocking mutations
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Penman, Bridget S. and Gandon, Sylvain (2020) Adaptive immunity selects against malaria infection blocking mutations. PLOS Computational Biology, 16 (10). e1008181. doi:10.1371/journal.pcbi.1008181 ISSN 1553-7358.
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Official URL: https://doi.org/10.1371/journal.pcbi.1008181
Abstract
The mutation responsible for Duffy negativity, which impedes Plasmodium vivax infection, has reached high frequencies in certain human populations. Conversely, mutations capable of blocking the more lethal P. falciparum have not succeeded in malarious zones. Here we present an evolutionary-epidemiological model of malaria which demonstrates that if adaptive immunity against the most virulent effects of malaria is gained rapidly by the host, mutations which prevent infection per se are unlikely to succeed. Our results (i) explain the rarity of strain-transcending P. falciparum infection blocking adaptations in humans; (ii) make the surprising prediction that mutations which block P. falciparum infection are most likely to be found in populations experiencing low or infrequent malaria transmission, and (iii) predict that immunity against some of the virulent effects of P. vivax malaria may be built up over the course of many infections.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QR Microbiology > QR180 Immunology | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Malaria -- Immunological aspects, Mutation (Biology), Adaptation (Biology) | |||||||||
Journal or Publication Title: | PLOS Computational Biology | |||||||||
Publisher: | Public Library of Science | |||||||||
ISSN: | 1553-7358 | |||||||||
Official Date: | 8 October 2020 | |||||||||
Dates: |
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Volume: | 16 | |||||||||
Number: | 10 | |||||||||
Article Number: | e1008181 | |||||||||
DOI: | 10.1371/journal.pcbi.1008181 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
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Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 28 October 2020 | |||||||||
Date of first compliant Open Access: | 2 November 2020 | |||||||||
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