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Data for Unraveling of a strongly correlated dynamical network of residues controlling the permeation of potassium in KcsA Ion Channel
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Cosseddu, Salvatore M., Choe, Eunju Julia and Khovanov, Igor A. (2021) Data for Unraveling of a strongly correlated dynamical network of residues controlling the permeation of potassium in KcsA Ion Channel. [Dataset]
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data_set (1).zip - Published Version Available under License Creative Commons Attribution 4.0. Download (268Kb) |
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Plain Text (Readme file)
readme (2).txt - Published Version Available under License Creative Commons Attribution 4.0. Download (1807b) |
Abstract
The complicated patterns of the single-channel currents in potassium ion channel KcsA are governed by the structural variability of the selectivity filter. A comparative analysis of the dynamics of the wild type KcsA channel and several of its mutants showing different conducting patterns was performed. A strongly correlated dynamical network of interacting residues is found to play a key role in regulating the state of the wild type channel. The network is centered on the aspartate D80 which plays the role of a hub by strong interacting via hydrogen bonds with residues E71, R64, R89, and W67. Residue D80 also affects the selectivity filter via its backbones. This network further compromises ions and water molecules located inside the channel that results in the mutual influence: the permeation depends on the configuration of residues in the network, and the dynamics of network’s residues depends on locations of ions and water molecules inside the selectivity filter. Some features of the network provide a further understanding of experimental results describing the KcsA activity. In particular, the necessity of anionic lipids to be present for functioning the channel is explained by the interaction between the lipids and the arginine residues R64 and R89 that prevents destabilizing the structure of the selectivity filter.
Item Type: | Dataset | ||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||||||
Type of Data: | Experimental data | ||||||||||||
Library of Congress Subject Headings (LCSH): | Ion channels, Molecular dynamics, Potassium channels | ||||||||||||
Publisher: | University of Warwick, School of Engineering | ||||||||||||
Official Date: | 12 January 2021 | ||||||||||||
Dates: |
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Status: | Not Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Media of Output (format): | .txt .pdb .gpl | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Copyright Holders: | University of Warwick | ||||||||||||
Description: | Data record consists of a zip archive, containing the raw data organised into subfolders according to figure in the corresponding article, and an accompanying readme file. |
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Date of first compliant deposit: | 12 January 2021 | ||||||||||||
Date of first compliant Open Access: | 12 January 2021 | ||||||||||||
RIOXX Funder/Project Grant: |
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