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Moderators of the effect of spinal manipulative therapy on pain relief and function in patients with chronic low back pain : an individual participant data meta-analysis

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de Zoete, Annemarie, de Boer, Michiel R., Rubinstein, Sidney M., van Tulder, Maurits W., Underwood, Martin, Hayden, Jill A., Buffart, Laurien M. and Ostelo, Raymond (2021) Moderators of the effect of spinal manipulative therapy on pain relief and function in patients with chronic low back pain : an individual participant data meta-analysis. Spine, 46 (8). E505-E517. doi:10.1097/BRS.0000000000003814 ISSN 0362-2436.

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Official URL: https://doi.org/10.1097/BRS.0000000000003814

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Abstract

Study design.
Individual participant data (IPD) meta-analysis

Objective.
To identify which participant characteristics moderate the effect of spinal manipulative therapy (SMT) on pain and functioning in chronic LBP.

Summary of Background.
The effects of SMT are comparable to other interventions recommended in guidelines for chronic low back pain (LBP); however, it is unclear which patients are more likely to benefit from SMT compared to other therapies.

Methods.
IPD were requested from randomized controlled trials (RCTs) examining the effect of SMT in adults with chronic LBP for pain and function compared to various other therapies (stratified by comparison). Potential patient moderators (n = 23) were a-priori based on their clinical-relevance. We investigated each moderator using a one-stage approach with IPD and investigated this interaction with the intervention for each time point (1, 3, 6 and 12 months).

Results.
We received IPD from 21/46 RCTs (n = 4223)). The majority (12 RCTs, n = 2249) compared SMT to recommended interventions. The duration of LBP, baseline pain (confirmatory), smoking and previous exposure to SMT (exploratory) had a small moderating effect across outcomes and follow-up points; these estimates did not represent minimally relevant differences in effects; for example, patients with less than one year of LBP demonstrated more positive point estimates for SMT vs recommended therapy for the outcome pain, (mean differences ranged from 4.97 (95% CI: -3.20 to 13.13) at three months, 10.76 (1.06 to 20.47) at six months to 5.26 (–2.92 to 13.44) at twelve months in patients with over a year LBP. No other moderators demonstrated a consistent pattern across time and outcomes. Few moderator analyses were conducted for the other comparisons because of too few data.

Conclusion.
We did not identify any moderators that enable clinicians to identify which patients are likely to benefit more from SMT compared to other treatments.

Item Type: Journal Article
Subjects: R Medicine > RD Surgery
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Backache, Backache -- Exercise therapy, Manipulation (Therapeutics), Spinal adjustment
Journal or Publication Title: Spine
Publisher: Lippincott Williams & Wilkins
ISSN: 0362-2436
Official Date: 15 April 2021
Dates:
DateEvent
15 April 2021Published
11 November 2020Available
17 September 2020Accepted
Volume: 46
Number: 8
Page Range: E505-E517
DOI: 10.1097/BRS.0000000000003814
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 18 November 2020
Date of first compliant Open Access: 11 May 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDEuropean Chiropractic Unionhttps://www.chiropractic-ecu.org/

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