The Library
Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
Tools
UNSPECIFIED (1999) Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion. MOLECULAR CELL, 3 (5). pp. 565-577. ISSN 1097-2765.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Abstract
The protooncogene c-myc regulates cell growth, differentiation, and apoptosis, and its aberrant expression is frequently observed in human cancer. However, the consequences of activating c-Myc in an adult tissue, in which these cellular processes are part of normal homeostasis, remain unknown. In order to achieve this, we have targeted expression of a switchable form of the c-Myc protein to the skin epidermis, a well characterized homeostatic tissue. We show that activation of c-MycER(TM) in adult suprabasal epidermis rapidly triggers proliferation and disrupts differentiation of postmitotic keratinocytes. Sustained activation of c-Myc is sufficient to induce papillomatosis together with angiogenesis-changes that resemble hyperplastic actinic keratosis, a commonly observed human precancerous epithelial lesion. All these premalignant changes spontaneously regress upon deactivation of c-MycER(TM).
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
||||
Journal or Publication Title: | MOLECULAR CELL | ||||
Publisher: | CELL PRESS | ||||
ISSN: | 1097-2765 | ||||
Official Date: | May 1999 | ||||
Dates: |
|
||||
Volume: | 3 | ||||
Number: | 5 | ||||
Number of Pages: | 13 | ||||
Page Range: | pp. 565-577 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |