Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research

Tools
- Tools
+ Tools

Alberti, Fabrizio, Kaleem, Saraa and Weaver, Jack (2020) Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research. Biology Open, 9 (12). bio056010. doi:10.1242/bio.056010 ISSN 2046-6390.

[img]
Preview
PDF
WRAP-recent-developements-basidiomycete-product-research-2020.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (809Kb) | Preview
Official URL: https://doi.org/10.1242/bio.056010

Request Changes to record.

Abstract

Basidiomycota are a large and diverse phylum of fungi. They can make bioactive metabolites that are used or have inspired the synthesis of antibiotics and agrochemicals. Terpenoids are the most abundant class of natural products encountered in this taxon. Other natural product classes have been described, including polyketides, peptides, and indole alkaloids. The discovery and study of natural products made by basidiomycete fungi has so far been hampered by several factors, which include their slow growth and complex genome architecture. Recent developments of tools for genome and metabolome studies are allowing researchers to more easily tackle the secondary metabolome of basidiomycete fungi. Inexpensive long-read whole-genome sequencing enables the assembly of high-quality genomes, improving the scaffold upon which natural product gene clusters can be predicted. CRISPR/Cas9-based engineering of basidiomycete fungi has been described and will have an important role in linking natural products to their genetic determinants. Platforms for the heterologous expression of basidiomycete genes and gene clusters have been developed, enabling natural product biosynthesis studies. Molecular network analyses and publicly available natural product databases facilitate data dereplication and natural product characterisation. These technological advances combined are prompting a revived interest in natural product discovery from basidiomycete fungi.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QK Botany
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Basidiomycota -- Metabolism, Basidiomycota -- Genetic aspects, Fungal metabolites, CRISPR-associated protein 9
Journal or Publication Title: Biology Open
Publisher: The Company of Biologists Ltd.
ISSN: 2046-6390
Official Date: 2 December 2020
Dates:
DateEvent
2 December 2020Published
UNSPECIFIEDAvailable
28 October 2020Accepted
Volume: 9
Number: 12
Article Number: bio056010
DOI: 10.1242/bio.056010
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 8 December 2020
Date of first compliant Open Access: 9 December 2020
Funder: The Leverhulme Trust [ECF- 2018-691] and the University of Warwick, through an Early Career Fellowship to F.A.; the Engineering and Physical Sciences Research Council and the Biotechnology and Biological Sciences Research Council [EP/L016494/1] for a scho
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
ECF-2018-691Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275
Early Career FellowshipUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
EP/L016494/1Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/L016494/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us