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Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
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Chhun, Audam, Sousoni, Despoina, Aguilo-Ferretjans, Maria del Mar, Song, Lijiang, Corre, Christophe and Christie-Oleza, Joseph A. (2021) Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica. Microbial Biotechnology, 14 (1). pp. 291-306. doi:10.1111/1751-7915.13722 ISSN 1751-7907.
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WRAP-Phytoplankton-trigger-production-crypticmetabolites-Salinisporatropica-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1381Kb) | Preview |
Official URL: https://doi.org/10.1111/1751-7915.13722
Abstract
Filamentous members of the phylum Actinobacteria are a remarkable source of natural products with pharmaceutical potential. The discovery of novel molecules from these organisms is, however, hindered because most of the biosynthetic gene clusters (BGCs) encoding these secondary metabolites are cryptic or silent and are referred to as orphan BGCs. While co‐culture has proven to be a promising approach to unlock the biosynthetic potential of many microorganisms by activating the expression of these orphan BGCs, it still remains an underexplored technique. The marine actinobacterium Salinispora tropica, for instance, produces valuable compounds such as the anti‐cancer molecule salinosporamide but half of its putative BGCs are still orphan. Although previous studies have used marine heterotrophs to induce orphan BGCs in Salinispora, its co‐culture with marine phototrophs has yet to be investigated. Following the observation of an antimicrobial activity against a range of phytoplankton by S. tropica, we here report that the photosynthate released by photosynthetic primary producers influences its biosynthetic capacities with production of cryptic molecules and the activation of orphan BGCs. Our work, using an approach combining metabolomics and proteomics, pioneers the use of phototrophs as a promising strategy to accelerate the discovery of novel natural products from marine actinobacteria.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QK Botany |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Phytoplankton, Primary productivity (Biology) , Marine productivity, Marine metabolites, Actinobacteria | ||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Microbial Biotechnology | ||||||||||||||||||||||||||||||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||||||||||||||||||||||||||||||
| ISSN: | 1751-7907 | ||||||||||||||||||||||||||||||||||||
| Official Date: | January 2021 | ||||||||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 14 | ||||||||||||||||||||||||||||||||||||
| Number: | 1 | ||||||||||||||||||||||||||||||||||||
| Page Range: | pp. 291-306 | ||||||||||||||||||||||||||||||||||||
| DOI: | 10.1111/1751-7915.13722 | ||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 12 January 2021 | ||||||||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 13 January 2021 | ||||||||||||||||||||||||||||||||||||
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