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Testing the independent and joint contribution of exposure to neurodevelopmental adversity and childhood trauma to risk of psychotic experiences in adulthood
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Liu, Yiwen, Mendonça, Marina, Cannon, Mary, Jones, Peter B, Lewis, Glyn, Thompson, Andrew D., Zammitt, Stanley and Wolke, Dieter (2021) Testing the independent and joint contribution of exposure to neurodevelopmental adversity and childhood trauma to risk of psychotic experiences in adulthood. Schizophrenia Bulletin, 47 (3). pp. 776-784. doi:10.1093/schbul/sbaa174 ISSN 0586-7614.
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Official URL: http://dx.doi.org/10.1093/schbul/sbaa174
Abstract
Exposure to neurodevelopmental adversity and childhood trauma are both independently associated with psychosis. However, there is little research on the mechanism underlying their relationship with each other. The current study investigated both the independent and joint effects of neurodevelopmental adversity and childhood trauma to better understand the etiology of psychosis. A large population-based cohort (N = 3514) followed from birth was assessed on psychotic experiences (PE) at 24 years. Neurodevelopmental adversity included obstetric complications (birth weight, gestational age, in-utero influenza exposure, resuscitation) and developmental impairment (cognitive and motor impairments). Trauma exposure included caregiver and peer inflicted trauma up to 17 years. Multiple regression models tested their independent and interactive effect on PE, and path analysis estimated the indirect effect of neurodevelopmental adversity on PE via trauma. Neurodevelopmental adversity (OR = 1.32, 95%CI: 1.08–1.62) and trauma (OR = 1.97, 95%CI: 1.65–2.36) independently increased the odds of PE. There was also an indirect relationship between neurodevelopmental adversity and PE via increased exposure to childhood trauma (β = 0.01, 95%CI: 0.004–0.024). In particular, peer bullying mediated the association between developmental impairment to PE (β = 0.02, 95%CI: 0.01–0.03). In conclusion, children with neurodevelopmental adversity, in particular those with developmental impairment, are more likely to be exposed to trauma. This new etiological understanding of psychosis suggests that PE may be partially modifiable through reducing exposure to peer bullying, especially in children with developmental impairment.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology H Social Sciences > HV Social pathology. Social and public welfare R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Psychoses , Psychoses in children, Psychoses in adolescence , Bullying , Children with disabilities -- Psychology, Neurodevelopmental treatment | |||||||||||||||||||||||||||
Journal or Publication Title: | Schizophrenia Bulletin | |||||||||||||||||||||||||||
Publisher: | Oxford University Press | |||||||||||||||||||||||||||
ISSN: | 0586-7614 | |||||||||||||||||||||||||||
Official Date: | May 2021 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 47 | |||||||||||||||||||||||||||
Number: | 3 | |||||||||||||||||||||||||||
Page Range: | pp. 776-784 | |||||||||||||||||||||||||||
DOI: | 10.1093/schbul/sbaa174 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Date of first compliant deposit: | 8 January 2021 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 11 January 2021 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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