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Aggregation-fragmentation model of robust concentration gradient formation
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Saunders, Timothy E. (2015) Aggregation-fragmentation model of robust concentration gradient formation. Physical Review E, 91 (2). 022704. doi:10.1103/PhysRevE.91.022704 ISSN 1539-3755.
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Official URL: http://dx.doi.org/10.1103/PhysRevE.91.022704
Abstract
Concentration gradients of signaling molecules are essential for patterning during development and they have been observed in both unicellular and multicellular systems. In subcellular systems, clustering of the signaling molecule has been observed. We develop a theoretical model of cluster-mediated concentration gradient formation based on the Becker-Döring equations of aggregation-fragmentation processes. We show that such a mechanism produces robust concentration gradients on realistic time and spatial scales so long as the process of clustering does not significantly stabilize the signaling molecule. Finally, we demonstrate that such a model is applicable to the pom1p subcellular gradient in fission yeast.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Physical Review E | ||||
Publisher: | American Physical Society | ||||
ISSN: | 1539-3755 | ||||
Official Date: | February 2015 | ||||
Dates: |
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Volume: | 91 | ||||
Number: | 2 | ||||
Article Number: | 022704 | ||||
DOI: | 10.1103/PhysRevE.91.022704 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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