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Impact of deprivation, dementia prevalence and regional demography on prescribing of anti‐dementia drugs in England : a time trend analysis
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Vohra, Neha, Hadi, Muhammad Abdul, Khanal, Saval, Kurmi, Om P. and Paudyal, Vibhu (2021) Impact of deprivation, dementia prevalence and regional demography on prescribing of anti‐dementia drugs in England : a time trend analysis. British Journal of Clinical Pharmacology, 87 (10). pp. 3747-3755. doi:10.1111/bcp.14782 ISSN 0306-5251.
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Official URL: https://bpspubs.onlinelibrary.wiley.com/doi/abs/10...
Abstract
Aim:
This study aimed to examine trends in prescribing of anti‐dementia drugs in primary care in England between 2009‐2019 and investigate the impact of deprivation, regional demography and disease prevalence on prescribing practices.
Methods:
Analysis of publicly available government data from various sources pertaining to primary care prescribing and demographics was conducted. All primary care prescription data pertaining to anti‐dementia drugs in England between 2009‐2019 were extracted and adjusted for inflation and populations changes. Data across English Clinical Commissioning regions were compared to explore the association between prescribing trend, deprivation, regional demography and dementia prevalence.
Results:
The number of prescription items for anti‐dementia drugs in England increased by approximately three‐folds (195.4%) from 24 items/1,000 populations in 2009 to 70.9 items/1,000 populations in 2019. In 2019, the least deprived areas had approximately twice the rate of prescribing of anti‐dementia drugs compared to the most deprived areas [median (IQR) values of 46.7 (36.6‐64.8) vs 91.23 (76.2‐95.1) items/1,000 populations respectively]. In the multivariable analysis, the number of prescription items showed an inverse relationship with deprivation [Coeff ‐0.046 95%CI:‐0.47 to ‐0.045] after adjustment of populations 65+ years and prevalence of dementia.
Conclusions:
The three‐fold rise in the number of prescription items for anti‐dementia drugs in the study period reflects the policy emphasis on early diagnosis and treatment of dementia. Higher rates of prescribing in the least deprived areas may be reflective of better and early diagnoses and access to treatments. Such inequality in access to the treatments needs to be investigated further.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Social Sciences > Warwick Business School > Behavioural Science Faculty of Social Sciences > Warwick Business School |
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| Library of Congress Subject Headings (LCSH): | Dementia, Dementia -- Patients -- Care, Dementia -- Treatment, Antipsychotic drugs , Drugs -- Prescribing -- England | ||||||||
| Journal or Publication Title: | British Journal of Clinical Pharmacology | ||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
| ISSN: | 0306-5251 | ||||||||
| Official Date: | October 2021 | ||||||||
| Dates: |
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| Volume: | 87 | ||||||||
| Number: | 10 | ||||||||
| Page Range: | pp. 3747-3755 | ||||||||
| DOI: | 10.1111/bcp.14782 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | This is the peer reviewed version of the following article: Vohra, N, Hadi, MA, Khanal, S, Kurmi, OP, Paudyal, V. Impact of deprivation, dementia prevalence and regional demography on prescribing of anti‐dementia drugs in England: a time trend analysis. Br J Clin Pharmacol. 2021. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1111/bcp.14782. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 22 February 2021 | ||||||||
| Date of first compliant Open Access: | 18 February 2022 | ||||||||
| RIOXX Funder/Project Grant: |
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