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Brain dynamics : synchronous peaks, functional connectivity, and its temporal variability
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Rolls, Edmund T., Cheng, Wei and Feng, Jianfeng (2021) Brain dynamics : synchronous peaks, functional connectivity, and its temporal variability. Human Brain Mapping, 42 (9). pp. 2790-2801. doi:10.1002/hbm.25404 ISSN 1065-9471.
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Official URL: http://dx.doi.org/10.1002/hbm.25404
Abstract
We describe advances in the understanding of brain dynamics that are important for understanding the operation of the cerebral cortex in health and disease. Peaks in the resting state fMRI BOLD signal in many different brain areas can become synchronized. In data from 1,017 participants from the Human Connectome Project, we show that early visual and connected areas have the highest probability of synchronized peaks. We show that these cortical areas also have low temporal variability of their functional connectivity. We show that there is an approximately reciprocal relation between the probability that a brain region will be involved in synchronized peaks and the temporal variability of the connectivity of a brain region. We show that a high probability of synchronized peaks and a low temporal variability of the connectivity of cortical areas are related to high mean functional connectivity, and provide an account of how these dynamics with some of the properties of avalanches arise. These discoveries help to advance our understanding of cortical operation in health, and in some mental disorders including schizophrenia.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Brain -- Localization of functions , Neural networks (Neurobiology), Computational neuroscience, Nervous system -- Imaging -- Data processing | |||||||||||||||||||||||||||
Journal or Publication Title: | Human Brain Mapping | |||||||||||||||||||||||||||
Publisher: | John Wiley and Sons | |||||||||||||||||||||||||||
ISSN: | 1065-9471 | |||||||||||||||||||||||||||
Official Date: | 15 June 2021 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 42 | |||||||||||||||||||||||||||
Number: | 9 | |||||||||||||||||||||||||||
Page Range: | pp. 2790-2801 | |||||||||||||||||||||||||||
DOI: | 10.1002/hbm.25404 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Date of first compliant deposit: | 31 March 2021 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 1 April 2021 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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