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Calcitonin secreting neuroendocrine neoplasms of the lung : a systematic review and narrative synthesis
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Llewellyn, David, Srirajaskanthan, Rajaventhan, Vincent, Royce, Guy, Catherine, Drakou, Eftychia E., Aylwin, Simon, Grossman, Ashley, Ramage, John K. and Dimitriadis, Georgios K. (2021) Calcitonin secreting neuroendocrine neoplasms of the lung : a systematic review and narrative synthesis. Endocrine Connections, 10 (4). pp. 447-461. doi:10.1530/EC-21-0071 ISSN 2049-3614.
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Official URL: https://doi.org/10.1530/EC-21-0071
Abstract
Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary thyroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, with cases of unnecessary thyroidectomy reported in the literature. This manuscript reports a case of ectopic hypercalcitonaemia from a metastatic neuroendocrine neoplasm of the lung with concurrent thyroid pathology and summarises the results of a systematic review of the literature. Medical Literature Analysis and Retrieval System Online, Excerpta Medica, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and SCOPUS databases were systematically and critically appraised for all peer reviewed manuscripts that suitably fulfilled the inclusion criteria established a priori. The protocol for this systematic review was developed according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, and followed methods outlined in The Cochrane Handbook for Systematic Reviews of Interventions. This systematic review is registered with PROSPERO. It is vital to consider diagnoses other than medullary thyroid carcinoma when presented with a patient with raised calcitonin, as it is not pathognomonic of medullary thyroid carcinoma. Lung neuroendocrine neoplasms can appear similar to medullary thyroid carcinoma histologically, they can secrete calcitonin and metastasize to the thyroid. Patients with medullary thyroid carcinoma may show stimulated calcitonin values over two or more times above the basal values, whereas calcitonin-secreting neuroendocrine neoplasms may or may not show response to stimulation tests. The present review summarises existing evidence from cases of ectopic hypercalcitonaemia to lung neuroendocrine neoplasms.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QR Microbiology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
Library of Congress Subject Headings (LCSH): | Calcitonin, Neuroendocrine tumors, Lungs -- Cancer, Paraneoplastic syndromes | ||||||
Journal or Publication Title: | Endocrine Connections | ||||||
Publisher: | BioScientifica | ||||||
ISSN: | 2049-3614 | ||||||
Official Date: | 26 April 2021 | ||||||
Dates: |
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Volume: | 10 | ||||||
Number: | 4 | ||||||
Page Range: | pp. 447-461 | ||||||
DOI: | 10.1530/EC-21-0071 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Copyright Holders: | © 2021 The authors 2021 | ||||||
Date of first compliant deposit: | 31 March 2021 | ||||||
Date of first compliant Open Access: | 1 April 2021 | ||||||
RIOXX Funder/Project Grant: |
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