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Exploratory study using urinary volatile organic compounds for the detection of hepatocellular carcinoma
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Bannaga, Ayman, Tyagi, Heena, Daulton, Emma, Covington, James A. and Arasaradnam, Ramesh P. (2021) Exploratory study using urinary volatile organic compounds for the detection of hepatocellular carcinoma. Molecules, 26 (9). 2447. doi:10.3390/molecules26092447
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Official URL: https://doi.org/10.3390/molecules26092447
Abstract
Hepatocellular carcinoma (HCC) biomarkers are lacking in clinical practice. We therefore explored the pattern and composition of urinary volatile organic compounds (VOCs) in HCC patients. This was done in order to assess the feasibility of a potential non-invasive test for HCC, and to enhance our understanding of the disease. This pilot study recruited 58 participants, of whom 20 were HCC cases and 38 were non-HCC cases. The non-HCC cases included healthy individuals and patients with various stages of non-alcoholic fatty liver disease (NAFLD), including those with and without fibrosis. Urine was analysed using gas chromatography–ion mobility spectrometry (GC–IMS) and gas chromatography–time-of-flight mass spectrometry (GC–TOF-MS). GC–IMS was able to separate HCC from fibrotic cases with an area under the curve (AUC) of 0.97 (0.91–1.00), and from non-fibrotic cases with an AUC of 0.62 (0.48–0.76). For GC-TOF-MS, a subset of samples was analysed in which seven chemicals were identified and tentatively linked with HCC. These include 4-methyl-2,4-bis(p-hydroxyphenyl)pent-1-ene (2TMS derivative), 2-butanone, 2-hexanone, benzene, 1-ethyl-2-methyl-, 3-butene-1,2-diol, 1-(2-furanyl)-, bicyclo(4.1.0)heptane, 3,7,7-trimethyl-, [1S-(1a,3β,6a)]-, and sulpiride. Urinary VOC analysis using both GC–IMS and GC-TOF-MS proved to be a feasible method of identifying HCC cases, and was also able to enhance our understanding of HCC pathogenesis.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Engineering Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||
| Library of Congress Subject Headings (LCSH): | Urine -- Analysis, Liver -- Cancer, Volatile organic compounds -- Health aspects | ||||||
| Journal or Publication Title: | Molecules | ||||||
| Publisher: | MDPI AG | ||||||
| ISSN: | 1420-3049 | ||||||
| Official Date: | 22 April 2021 | ||||||
| Dates: |
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| Volume: | 26 | ||||||
| Number: | 9 | ||||||
| Article Number: | 2447 | ||||||
| DOI: | 10.3390/molecules26092447 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
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