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Synthesis and anti-invasive activity of novel 1,3 -diarylpropenones
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UNSPECIFIED (1998) Synthesis and anti-invasive activity of novel 1,3 -diarylpropenones. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 37 (7). pp. 628-643. ISSN 0376-4699.
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Abstract
Thirty two novel 1,3-diarylpropenones (chalcones) have been synthesised by Claisen-Schmidt condensation. Twenty six of them are new compounds and have been fully characterised from their spectral data. The structures of five chalcones have also been confirmed by X-ray crystallography. Twenty one differently substituted chalcones have been tested against the invasion of human MCF-7/6 mammary carcinoma cells, five chalcones have been found to exhibit potent anti-invasive activity. Seven out of thirty two chalcones synthesised show herbicidal activity of interest.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | ||||
Publisher: | NATL INST SCIENCE COMMUNICATION | ||||
ISSN: | 0376-4699 | ||||
Official Date: | July 1998 | ||||
Dates: |
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Volume: | 37 | ||||
Number: | 7 | ||||
Number of Pages: | 16 | ||||
Page Range: | pp. 628-643 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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