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Middle cerebral artery occlusion in the rat causes a biphasic production of immunoreactive interleukin-1 beta in the cerebral cortex
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UNSPECIFIED (1998) Middle cerebral artery occlusion in the rat causes a biphasic production of immunoreactive interleukin-1 beta in the cerebral cortex. NEUROSCIENCE LETTERS, 249 (2-3). pp. 177-179. ISSN 0304-3940.
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Abstract
Interleukin-1 beta (IL-1 beta) has been implicated in the sequence of events leading to neuronal cell death. We have used an ultrasensitive, highly specific immunometric assay for rat IL-1 beta to determine the pattern of protein expression in the rat cerebral cortex following middle cerebral artery occlusion. In the ipsilateral cerebral cortex there was a biphasic pattern of production with a rapid early phase of IL-1 beta expression followed by a delayed phase at 4 h which was sustained for up to 72 h. There was a similar but smaller expression of 1L-1 beta in the contralateral cortex. Sham operated animals showed no IL-1 beta expression. These results provide further evidence to show that IL-1 beta is expressed in the rat cerebral cortex following cerebral ischaemia. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
Journal or Publication Title: | NEUROSCIENCE LETTERS | ||||
Publisher: | ELSEVIER SCI IRELAND LTD | ||||
ISSN: | 0304-3940 | ||||
Official Date: | 19 June 1998 | ||||
Dates: |
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Volume: | 249 | ||||
Number: | 2-3 | ||||
Number of Pages: | 3 | ||||
Page Range: | pp. 177-179 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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