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Seeking insights into aging through yeast mitochondrial electrophysiology
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de Souza-Guerreiro, Tailise Carolina and Asally, Munehiro (2021) Seeking insights into aging through yeast mitochondrial electrophysiology. Bioelectricity, 3 (2). pp. 111-115. doi:10.1089/bioe.2021.0011 ISSN 2576-3105.
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Official URL: https://doi.org/10.1089/bioe.2021.0011
Abstract
During aging, mitochondrial membrane potential, a key indicator for bioenergetics of cells, depolarizes in a wide range of species—from yeasts, plants to animals. In humans, the decline of mitochondrial activities can impact the high-energy-consuming organs, such as the brain and heart, and increase the risks of age-linked diseases. Intriguingly, a mild depolarization of mitochondria has lifespan-extending effects, suggesting an important role played by bioelectricity during aging. However, the underpinning biophysical mechanism is not very well understood due in part to the difficulties associated with a multiscale process. Budding yeast Saccharomyces cerevisiae could provide a model system to bridge this knowledge gap and provide insights into aging. In this perspective, we overview recent studies on the yeast mitochondrial membrane electrophysiology and aging and call for more electrochemical and biophysical studies on aging.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QK Botany Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Aging, Mitochondrial membranes, Electrophysiology, Saccharomyces cerevisiae | |||||||||
| Journal or Publication Title: | Bioelectricity | |||||||||
| Publisher: | Mary Ann Liebert | |||||||||
| ISSN: | 2576-3105 | |||||||||
| Official Date: | June 2021 | |||||||||
| Dates: |
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| Volume: | 3 | |||||||||
| Number: | 2 | |||||||||
| Page Range: | pp. 111-115 | |||||||||
| DOI: | 10.1089/bioe.2021.0011 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Reuse Statement (publisher, data, author rights): | Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/bioe.2021.0011 | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| Date of first compliant deposit: | 22 July 2021 | |||||||||
| Date of first compliant Open Access: | 16 June 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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